Recombinant Human TSHR Protein, His-tagged

• Cat.No.: TSHR-127H
• Product Overview: Recombinant Human TSHR Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.0 added with 300mM Imidazole and 0.7% Sarcosyl, 15% glycerol
• Molecular Mass: 27.4 kDa
• AA Sequence: MKKGHHHHHHGMGCSSPPCECHQEE DFRVTCKDIQRIPSLPPSTQTLKLI ETHLRTIPSHAFSNLPNISRIYVSI DVTLQQLESHSFYNLSKVTHIEIRN TRNLTYIDPDALKELPLLKFLGIFN TGLKMFPDLTKVYSTDIFFILEITD NPYMTSIPVNAFQGLCNETLTLKLY NNGFTSVQGYAFNGTKLDAVYLNKN KYLTVIDKDAFGGVYSGPSLLDVSQ TSVTALPSKGLEHLKELI
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 1.6 mg/ml

Gene Information

• Gene Name: TSHR thyroid stimulating hormone receptor [ Homo sapiens (human) ]
• Official Symbol: TSHR
• Synonyms: LGR3; CHNG1; hTSHR-I
• Gene ID: 7253
• mRNA Refseq: NM_000369
• Protein Refseq: NP_000360
• MIM: 603372
• UniProt ID: P16473