Recombinant Human TSHR Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: TSHR-6685H
• Product Overview: TSHR MS Standard C13 and N15-labeled recombinant protein (NP_001136098) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 30.8 kDa
• AA Sequence: MRPADLLQLVLLLDLPRDLGGMGCS SPPCECHQEEDFRVTCKDIQRIPSL PPSTQTLKLIETHLRTIPSHAFSNL PNISRIYVSIDVTLQQLESHSFYNL SKVTHIEIRNTRNLTYIDPDALKEL PLLKFLGIFNTGLKMFPDLTKVYST DIFFILEITDNPYMTSIPVNAFQGL CNETLTLKLYNNGFTSVQGYAFNGT KLDAVYLNKNKYLTVIDKDAFGGVY SGPSLLVENVAVSGKGFCKSLFSWL YRLPLGRKSLSFETQKAPRSSMPST RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: TSHR thyroid stimulating hormone receptor [ Homo sapiens (human) ]
• Official Symbol: TSHR
• Synonyms: TSHR; thyroid stimulating hormone receptor; thyrotropin receptor; LGR3; TSH-R; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid-stimulating hormone receptor; thyroid stimulating hormone receptor, isoform 2; CHNG1; hTSHR-I; MGC75129
• Gene ID: 7253
• mRNA Refseq: NM_001142626
• Protein Refseq: NP_001136098
• MIM: 603372
• UniProt ID: P16473