Recombinant Human TXNRD1 Protein

Cat.No. : TXNRD1-22H
Product Overview : Recombinant Human Thioredoxin Reductase 1 (Non-tagged, 499 residues)
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Description : The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Species : Human
Tag : Tag Free
Purity : ≥ 95% as judged by gel analysis
Unit Definition : 1 U of enzyme reduces 1 μmol DTNB per min in 0.5 mL standard DTNB assay containing 2.5 mM DTNB and 0.3 mM NADPH in TE buffer (50 mM Tris-HCl, 2 mM EDTA, pH 7.5)
Applications : DTNB assay; Insulin-coupled Thioredoxin assay; Inhibitor screening; etc.
Notes : Centrifuge the tube briefly before opening the lid
Storage : Store at -20 centigrade upon delivery.
Concentration : 1 mg/mL
Storage Buffer : TE buffer with 50% glycerol.
Shipping : Shipped in cold pack by courier service.
FACS: Lane 1: Molecular weight marker<br />Lane 2: HTRXR1
Gene Name : TXNRD1 thioredoxin reductase 1 [ Homo sapiens (human) ]
Official Symbol : TXNRD1
Synonyms : TXNRD1; thioredoxin reductase 1; TR; TR1; TXNR; TRXR1; GRIM-12; thioredoxin reductase 1, cytoplasmic; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; oxidoreductase; peroxidase TXNRD1; selenoprotein TXNRD1; testis tissue sperm-binding protein Li 46a; thioredoxin reductase GRIM-12; thioredoxin reductase TR1; EC; EC
Gene ID : 7296
mRNA Refseq : NM_182743
Protein Refseq : NP_877420
MIM : 601112
UniProt ID : Q16881

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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