Recombinant Human Thioredoxin reductase 1 Protein, His-tagged

Cat.No. : TXNRD1-32H
Product Overview : Recombinant human TXNRD1 protein with a His-tag was expressed in HEK293
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Description : The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.
Source : HEK293
Species : Human
Tag : His
Molecular Mass : The protein has a calculated MW of 72 kDa.
AA Sequence : HHHHHHHHMGCAEGKAVAAAAPTEL QTKGKNGDGRRRSAKDHHPGKTLPE NPAGFTSTATADSRALLQAYIDGHS VVIFSRSTCTRCTEVKKLFKSLCVP YFVLELDQTEDGRALEGTLSELAAE TDLPVVFVKQRKIGGHGPTLKAYQE GRLQKLLKMNGPEDLPKSYDYDLII IGGGSGGLAAAKEAAQYGKKVMVLD FVTPTPLGTRWGLGGTCVNVGCIPK KLMHQAALLGQALQDSRNYGWKVEE TVKHDWDRMIEAVQNHIGSLNWGYR VALREKKVVYENAYGQFIGPHRIKA TNNKGKEKIYSAERFLIATGERPRY LGIPGDKEYCISSDDLFSLPYCPGK TLVVGASYVALECAGFLAGIGLDVT VMVRSILLRGFDQDMANKIGEHMEE HGIKFIRQFVPIKVEQIEAGTPGRL RVVAQSTNSEEIIEGEYNTVMLAIG RDACTRKIGLETVGVKINEKTGKIP VTDEEQTNVPYIYAIGDILEDKVEL TPVAIQAGRLLAQRLYAGSTVKCDY ENVPTTVFTPLEYGACGLSEEKAVE KFGEENIEVYHSYFWPLEWTIPSRD NNKCYAKIICNTKDNERVVGFHVLG PNAGEVTQGFAAALKCGLTKKQLDS TIGIHPVCAEVFTTLSVTKRSGASI LQAGCCG
Purity : >90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 3.71 mg/mL
Storage Buffer : 20 mM Tris +150 mM NaCl, pH8.4
SDS-PAGE: Reducing 12% SDS-PAGE and WB analysis profile of purified TXNRD1<br />1. TXNRD1<br />2. BSA
Gene Name : TXNRD1 thioredoxin reductase 1 [ Homo sapiens (human) ]
Official Symbol : TXNRD1
Synonyms : TXNRD1; thioredoxin reductase 1; thioredoxin reductase 1, cytoplasmic; GRIM 12; Trxr1; TXNR; oxidoreductase; thioredoxin reductase TR1; thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; TR; TR1; TRXR1; GRIM-12; MGC9145;
Gene ID : 7296
mRNA Refseq : NM_001093771
Protein Refseq : NP_001087240
MIM : 601112
UniProt ID : Q16881

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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