Recombinant Human tyrosinase Protein, His tagged

• Cat.No.: TYR-13H
• Product Overview: Purified recombinant protein of Human tyrosinase (affected in oculocutaneous albinism IA) (TYR), His19-Phe320, with N-terminal His tag, expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 19-320 aa
• Description: The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3'' half of this gene.
• Tag: N-His
• Molecular Mass: 34.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Concentration: > 0.05 μg/μL as determined by microplate BCA method

Gene Information

• Gene Name: TYR tyrosinase [ Homo sapiens (human) ]
• Official Symbol: TYR
• Synonyms: TYR; tyrosinase; ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; tyrosinase; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB; EC 1.14.18.1
• Gene ID: 7299
• mRNA Refseq: NM_000372
• Protein Refseq: NP_000363
• MIM: 606933
• UniProt ID: P14679