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Active Recombinant Human UBE2K Protein, His-tagged

Cat.No. : UBE2K-649H
Product Overview : Recombinant Human UBE2K fused with His tag at N-terminal was expressed in E. coli.
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Description : UBE2K also known as UBC1 or ubiquitin-conjugating enzyme E2K belongs to the ubiquitin-conjugating enzyme family which interacts with RING finger proteins. UBE2K can ubiquitinate huntingtin, the gene product for Huntington's disease. Huntingtin is ubiquitinated in peripheral cells, suggesting a role for UBE2K in the degradation of huntingtin. UBE2K plays a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases. UBE2K also plays a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation.
Source : E. coli
Species : Human
Tag : His
Form : 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Bio-activity : 11 nmol/min/mg
Molecular Mass : 26 kDa
Purity : >95%
Applications : Ubiquitin Enzyme Assay, Western Blot
Stability : 1 year at - 70 centigrade from the date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ml
Gene Name : UBE2K ubiquitin-conjugating enzyme E2K [ Homo sapiens ]
Official Symbol : UBE2K
Synonyms : UBE2K; ubiquitin-conjugating enzyme E2K; HIP2, huntingtin interacting protein 2 , ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-conjugating enzyme E2 K; HYPG; UBC1; HIP-2; E2(25K); ubiquitin-protein ligase; ubiquitin carrier protein; huntingtin interacting protein 2; huntingtin-interacting protein 2; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); LIG; HIP2; E2-25K; DKFZp564C1216; DKFZp686J24237;
Gene ID : 3093
mRNA Refseq : NM_005339
Protein Refseq : NP_005330
MIM : 602846
UniProt ID : P61086

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is UBE2K a potential biomarker for any diseases? 06/14/2021

UBE2K expression levels are being investigated as potential biomarkers for certain cancers and neurodegenerative diseases, offering insights into disease progression and prognosis.

How does UBE2K influence protein quality control in cells? 03/04/2021

UBE2K is involved in the ubiquitination of misfolded or damaged proteins, marking them for degradation, thus contributing to protein quality control mechanisms within cells.

Can targeting UBE2K be a strategy for personalized medicine? 05/03/2020

The potential role of UBE2K as a therapeutic target suggests that personalized medicine approaches could be developed based on the specific molecular characteristics of a patient's disease.

Are there any known genetic variations in the UBE2K gene associated with diseases? 06/08/2019

Genetic variations in the UBE2K gene have been explored for associations with certain diseases, providing insights into the genetic basis of UBE2K-related disorders.

How does UBE2K contribute to the immune response? 06/28/2017

UBE2K is involved in the ubiquitination of proteins in the immune signaling pathways, influencing the immune response and inflammation.

Customer Reviews (3)

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Reviews
12/05/2022

    This protein is known for its exceptional quality and purity, providing reliable and consistent results.

    12/20/2021

      Its high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.

      10/13/2016

        The UBE2K protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.

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