Recombinant Human UGT1A8 Protein
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Cat.No. : | UGT1A8-99H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant human UGT1A8 protein without tag was expressed in insect cells. |
Description : | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. |
Source : | Insect cells |
Species : | Human |
Bio-activity : | UGT Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 100 mM Tris-HCl (pH 7.5) containing 5 mM magnesium chloride and 2 mM UDPGA. Alamethicin (10 μg/ml final concentration) is added to kinetics tests only) Substrate: 4-methylumbelliferone Linear with time up to: 30 min(Determined at 300 μM substrate, using a protein concentration of 100 μg/ml) Linear with protein up to: 400 μg/ml(Determined at 300 μM substrate, using an incubation time of 5 min) Vmax: 16227 pmol/min/mg protein Km: 510 μM |
Usage : | For laboratory (research) purposes only |
Storage : | Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice. |
Concentration : | Protein Concentration: 5 mg/ml |
Storage Buffer : | 25 mM Tris-acetate (pH 7.6), 10% (v/v) glycerol, 1 mM EDTA |
Gene Name : | UGT1A8 UDP glucuronosyltransferase family 1 member A8 [ Homo sapiens (human) ] |
Official Symbol : | UGT1A8 |
Synonyms : | UGT1A8; UDP glucuronosyltransferase family 1 member A8; GNT1; UGT1; UDPGT; UGT1A; UGT1H; UGT-1A; UGT-1H; UGT1.1; UGT1.8; UGT1A1; UGT1-01; UGT1-08; UGT1A8S; hUG-BR1; UDPGT 1-8; UDP-glucuronosyltransferase 1-8; Bilirubin-specific UDPGT isozyme 1; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A8; UDPGT 1-1 |
Gene ID : | 54576 |
mRNA Refseq : | NM_019076 |
Protein Refseq : | NP_061949 |
MIM : | 606433 |
UniProt ID : | Q9HAW9 |
◆ Recombinant Protein
UGT1A8-2310H | Recombinant Human UGT1A8 Protein, His (Fc)-Avi-tagged | +Inquiry |
UGT1A8-511H | Recombinant Human UGT1A8 Protein, MYC/DDK-tagged | +Inquiry |
|
UGT2B10UGT1A1UGT1A10UGT1A3UGT1A6UGT1A9UGT2B4UGT1A7UGT2B15UGT2B17UGT2B7UGT3A1UGT3A2UGT1A4UGT1A5UGT2A3UGT2B11Ugt8aUgt1a2Ugt1a6aUgt1a7cUGT1A8UGT2A1Ugt2b5UGT8Ugt1a6bUgt2a2Ugt2b1UGT2B28Ugt2b34Ugt2b35Ugt2b36Ugt2b37Ugt2b38Ugt2b
Easy access to products and services you need from our library via powerful searching tools.
Copyright © 2023 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy