Recombinant Human UGT1A8 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : UGT1A8-2989H
Product Overview : UGT1A8 MS Standard C13 and N15-labeled recombinant protein (NP_061949) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 57.1 kDa
AA Sequence : MARTGWTSPIPLCVSLLLTCGFAEA GKLLVVPMDGSHWFTMQSVVEKLIL RGHEVVVVMPEVSWQLGKSLNCTVK TYSTSYTLEDLDREFMDFADAQWKA QVRSLFSLFLSSSNGFFNLFFSHCR SLFNDRKLVEYLKESSFDAVFLDPF DACGLIVAKYFSLPSVVFARGIACH YLEEGAQCPAPLSYVPRILLGFSDA MTFKERVRNHIMHLEEHLFCQYFSK NALEIASEILQTPVTAYDLYSHTSI WLLRTDFVLDYPKPVMPNMIFIGGI NCHQGKPLPMEFEAYINASGEHGIV VFSLGSMVSEIPEKKAMAIADALGK IPQTVLWRYTGTRPSNLANNTILVK WLPQNDLLGHPMTRAFITHAGSHGV YESICNGVPMVMMPLFGDQMDNAKR METKGAGVTLNVLEMTSEDLENALK AVINDKSYKENIMRLSSLHKDRPVE PLDLAVFWVEFVMRHKGAPHLRPAA HDLTWYQYHSLDVIGFLLAVVLTVA FITFKCCAYGYRKCLGKKGRVKKAH KSKTHTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : UGT1A8 UDP glucuronosyltransferase family 1 member A8 [ Homo sapiens (human) ]
Official Symbol : UGT1A8
Synonyms : UGT1A8; UDP glucuronosyltransferase family 1 member A8; GNT1; UGT1; UDPGT; UGT1A; UGT1H; UGT-1A; UGT-1H; UGT1.1; UGT1.8; UGT1A1; UGT1-01; UGT1-08; UGT1A8S; hUG-BR1; UDPGT 1-8; UDP-glucuronosyltransferase 1A8; Bilirubin-specific UDPGT isozyme 1; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A1; UDPGT 1-1; EC 2.4.1.17
Gene ID : 54576
mRNA Refseq : NM_019076
Protein Refseq : NP_061949
MIM : 606433
UniProt ID : Q9HAW9

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