Recombinant Human UROS Protein, His-tagged

• Cat.No.: UROS-622H
• Product Overview: Recombinant Human UROS(Met1-Cys265) fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
• Source: E. coli
• Species: Human
• Tag: His
• Form: 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, pH 8.0. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 29.7 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: UROS uroporphyrinogen III synthase [ Homo sapiens ]
• Official Symbol: UROS
• Synonyms: UROS; uroporphyrinogen III synthase; uroporphyrinogen-III synthase; congenital erythropoietic porphyria; hydroxymethylbilane hydrolyase; uroporphyrinogen-III cosynthase; UROIIIS
• Gene ID: 7390
• mRNA Refseq: NM_000375
• Protein Refseq: NP_000366
• MIM: 606938
• UniProt ID: P10746