Recombinant Human UROS, His-tagged

• Cat.No.: UROS-31080TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-265 of Human UROS, with N terminal His tag; Predicted MWt 30 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-265 a.a.
• Description: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunthers disease).
• Conjugation: HIS
• Tissue specificity: Ubiquitous.
• Form: Lyophilised:Reconstitute with 148 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEF LSLPSFSEKLSHPEDYGGLIFTSPRAVEAAELCLEQNN KTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEG ETCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKA LKDKGIAMESITVYQTVAHPGIQGNLNSYYSQQGVPASIT FFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARAL AAQGLPVSCTAESPTPQALATGIRKALQPHGCC
• Sequence Similarities: Belongs to the uroporphyrinogen-III synthase family.
• Full Length: Full L.

Gene Information

• Gene Name: UROS uroporphyrinogen III synthase [ Homo sapiens ]
• Official Symbol: UROS
• Synonyms: UROS; uroporphyrinogen III synthase; uroporphyrinogen-III synthase; congenital erythropoietic porphyria
• Gene ID: 7390
• mRNA Refseq: NM_000375
• Protein Refseq: NP_000366
• MIM: 606938
• Uniprot ID: P10746
• Chromosome Location: 10q25.2-q26.3
• Pathway: Heme Biosynthesis, organism-specific biosystem; Heme biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem
• Function: cofactor binding; lyase activity; uroporphyrinogen-III synthase activity; uroporphyrinogen-III synthase activity