Recombinant Human VCP Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: VCP-6354H
• Product Overview: VCP MS Standard C13 and N15-labeled recombinant protein (NP_009057) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 89.3 kDa
• AA Sequence: MASGADSKGDDLSTAILKQKNRPNR LIVDEAINEDNSVVSLSQPKMDELQ LFRGDTVLLKGKKRREAVCIVLSDD TCSDEKIRMNRVVRNNLRVRLGDVI SIQPCPDVKYGKRIHVLPIDDTVEG ITGNLFEVYLKPYFLEAYRPIRKGD IFLVRGGMRAVEFKVVETDPSPYCI VAPDTVIHCEGEPIKREDEEESLNE VGYDDIGGCRKQLAQIKEMVELPLR HPALFKAIGVKPPRGILLYGPPGTG KTLIARAVANETGAFFFLINGPEIM SKLAGESESNLRKAFEEAEKNAPAI IFIDELDAIAPKREKTHGEVERRIV SQLLTLMDGLKQRAHVIVMAATNRP NSIDPALRRFGRFDREVDIGIPDAT GRLEILQIHTKNMKLADDVDLEQVA NETHGHVGADLAALCSEAALQAIRK KMDLIDLEDETIDAEVMNSLAVTMD DFRWALSQSNPSALRETVVEVPQVT WEDIGGLEDVKRELQELVQYPVEHP DKFLKFGMTPSKGVLFYGPPGCGKT LLAKAIANECQANFISIKGPELLTM WFGESEANVREIFDKARQAAPCVLF FDELDSIAKARGGNIGDGGGAADRV INQILTEMDGMSTKKNVFIIGATNR PDIIDPAILRPGRLDQLIYIPLPDE KSRVAILKANLRKSPVAKDVDLEFL AKMTNGFSGADLTEICQRACKLAIR ESIESEIRRERERQTNPSAMEVEED DPVPEIRRDHFEEAMRFARRSVSDN DIRKYEMFAQTLQQSRGFGSFRFPS GNQGGAGPSQGSGGGTGGSVYTEDN DDDLYGTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: VCP valosin containing protein [ Homo sapiens (human) ]
• Official Symbol: VCP
• Synonyms: VCP; valosin containing protein; transitional endoplasmic reticulum ATPase; IBMPFD; p97; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; TERA; ALS14; MGC8560; MGC131997; MGC148092
• Gene ID: 7415
• mRNA Refseq: NM_007126
• Protein Refseq: NP_009057
• MIM: 601023
• UniProt ID: P55072

Reviews

08/19/2022

This can involve organizing conferences, workshops, and webinars to discuss the latest advancements, share research findings, and broaden the understanding of VCP function.

01/30/2022

Researchers have successfully utilized VCP protein in electron microscopy studies, unraveling crucial insights into protein interactions and conformational changes.

04/23/2019

The exceptional performance of VCP protein in both ELISA and protein electron microscopy structure analysis positions it as a valuable tool in a broad range of research applications.

Q&As

Can abnormalities in the VCP protein be detected through genetic testing?

Yes, genetic testing can identify mutations in the VCP gene, aiding in the diagnosis of VCP-related disorders.

Can VCP protein levels be used as a diagnostic marker for specific diseases?

Currently, VCP protein levels are not widely used as a diagnostic marker, but ongoing research may reveal its potential utility in the future.

Is the VCP protein a potential target for drug development?

The potential therapeutic targeting of VCP is an area of active research, with efforts to develop drugs that modulate its activity for the treatment of specific diseases.

Can changes in the VCP protein be indicative of other health conditions besides neurodegenerative diseases and cancer?

Yes, alterations in VCP function may contribute to various health conditions, including autoimmune diseases and metabolic disorders.

How does the VCP protein relate to cellular protein quality control?

VCP plays a crucial role in eliminating misfolded or damaged proteins, contributing to cellular protein quality control mechanisms.