Recombinant Human VEGFA

• Cat.No.: VEGFA-P1003H
• Product Overview: Recombinant human VEGFA fused with6His was produced in CHO cells.

Specification

• Cat. No.: VEGFA-P1003H
• Description: Vascularendothelial growth factor (VEGFA) is a mitogen that specifically acts onendo- thelial cells and has various effects, including mediating increasedvascular permeability and inducing angiogenesis , cell growth, migration, andinhibition of apoptosis. It is a pivotal stimulator of angiogenesis becauseits binding to VEGF receptors has been shown to promote endothelial cellmigration and proliferation, two key features required for the development ofnew blood vessels. In addition, VEGF-A increases vascular permeability, whichmay also contribute to angiogenesis and tumor growth. Recognition of thecentral role of VEGF-A in angiogenesis has led to the hypothesis that itsinhibition may represent a novel and effective approach to the treatment ofcancer and other conditions characterized by pathologic angiogenesis.
• ProteinConstruction: Recombinanthuman VEGFA is combined the Sequence of VEFGA with 6His.
• Source: ChineseHamster Ovary (CHO cell)
• Purity: >95%as determined by SDS-PAGE and HPLC
• Endotoxin: <1.0EU per 10 mg protein as determined by the LAL method
• Stability: Samplesare stable for up to six months from date of receipt at -20℃ and are stable fortwo months at 4℃.
• Molecular Mass: Recombinanthuman VEGFA comprises 342 amino acid residues, combining 6His, The MW is25kDa under reducing conditions.
• Predicted N terminal: APMAEGGGQN
• Formulation: Normally20-50mM NaAC-HAC and 100-150 mM NaCl are added, pH 5.0-6.0.
• Storage: Store itunder sterile conditions at -70℃upon receiving. Recommend to pack the protein intosmaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: VEGFA vascular endothelial growth factor A [ Homo sapiens ]
• Official Symbol: VEGFA
• Synonyms: VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1;VEGF-A; MGC70609; vascular permeability factor; vascular endothelial growthfactor isoform VEGF165; vascular endothelial growth factor
• Gene ID: 7422
• mRNA Refseq: NM_001025366
• Protein Refseq: NP_001020537
• MIM: 192240
• UniProt ID: P15692
• Chromosome Location: 6p12
• Pathway: Cytokine-cytokinereceptor interaction; Focal adhesion; Pancreatic cancer; Renal cellcarcinoma; VEGF signaling pathway; mTOR signaling pathway; Hemostasis;Signaling by VEGF
• Function: cellsurface binding; chemoattractant activity; cytokine activity