Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1, His-tagged

• Cat.No.: VOPP1-697H
• Product Overview: VOPP1, 82-172aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 82-172 a.a.
• Description: Vesicular, overexpressed in cancer, prosurvival protein 1(VOPP1), also known as Glioblastoma-amplified secreted protein (GASP), has been previously shown to be over-expressed in human glioblastoma multiforme and squamous cell carcinoma. VOPP1 is a key regulator of NF-kappaB signaling, and that high-level, amplification-mediated VOPP1 expression, such as that occurring in tumors with amplified EGFR, could contribute to resistance to apoptosis. Recombinant human VOPP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.2M NaCl
• Molecular Mass: 12 kDa (112aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 [ Homo sapiens ]
• Official Symbol: VOPP1
• Synonyms: VOPP1; vesicular, overexpressed in cancer, prosurvival protein 1; DKFZp564K0822; ECop; EGFR coamplified and overexpressed protein; FLJ20532; GASP; Glioblastoma amplified secreted protein; Glioblastoma-amplified secreted protein; EGFR-coamplified and overexpressed protein; putative NF-kappa-B-activating protein 055N; ECOP
• Gene ID: 81552
• mRNA Refseq: NM_030796
• Protein Refseq: NP_110423
• MIM: 611915
• UniProt ID: Q96AW1
• Chromosome Location: 7p11.2
• Function: signal transducer activity