Recombinant Human VHL Protein, DYKDDDDK-tagged

• Cat.No.: VHL-28605H
• Product Overview: Recombinant protein from the full-length sequence of homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1 (NM_000551), with a DYKDDDDK tag was expressed in human cells.

Specification

• Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Source: Human cells
• Species: Human
• Tag: DYKDDDDK
• Molecular Mass: 24 kDa
• Endotoxin: < 0.1 ng/ μg of protein (< 1 EU/ μg)
• Purity: > 90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Gene Information

• Gene Name: VHL von Hippel-Lindau tumor suppressor [ Homo sapiens (human) ]
• Official Symbol: VHL von Hippel-Lindau tumor suppressor [ Homo sapiens (human) ]
• Synonyms: VHL; von Hippel-Lindau tumor suppressor; RCA1; VHL1; pVHL; HRCA1; von Hippel-Lindau disease tumor suppressor; elongin binding protein; protein G7; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
• Gene ID: 7428
• mRNA Refseq: NM_000551
• Protein Refseq: NP_000542
• MIM: 608537
• UniProt ID: P40337