Recombinant Mouse Abi1 Protein, MYC/DDK-tagged Abi1-501M

Recombinant Mouse Abi1 Protein, MYC/DDK-tagged


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Recombinant Mouse Abi1 Protein, MYC/DDK-tagged

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Cat.No. : Abi1-501M
Product Overview : Purified recombinant protein of full-length mouse abl-interactor 1 (Abi1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Source : HEK293T
Species : Mouse
Molecular Mass : 51.7 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Abi1 abl-interactor 1 [ Mus musculus (house mouse) ]
Official Symbol : Abi1
Synonyms : Abi1; abl-interactor 1; E3B1; NAP1; abi-1; Ssh3bp1; abl interactor 1; abelson interactor 1; ablphilin-1; eps8 SH3 domain-binding protein; eps8 binding protein; spectrin SH3 domain binding protein 1
Gene ID : 11308
mRNA Refseq : NM_007380
Protein Refseq : NP_031406
UniProt ID : Q8CBW3
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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