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Recombinant Mouse Adcy9 protein, His & GST-tagged

Cat.No. : Adcy9-6944M
Product Overview : Recombinant Mouse Adcy9 aa. (Thr852~Val1065 (Accession # P51830)) fused with N-terminal His & GST tag was produced in E. coli cells.
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Source : E. coli
Species : Mouse
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 54.1kDa
Protein length : Thr852~Val1065 (Accession # P51830)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.8.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Adcy9 adenylate cyclase 9 [ Mus musculus (house mouse) ]
Official Symbol : Adcy9
Synonyms : Adcy9; adenylate cyclase 9; AC9; ACtp10; AW125421; D16Wsu65e; mKIAA0520; adenylate cyclase type 9; ATP pyrophosphate-lyase 9; adenylate cyclase type IX; adenylyl cyclase 9; adenylyl cyclase type 10
Gene ID : 11515
mRNA Refseq : NM_009624.3
Protein Refseq : NP_033754.2
UniProt ID : P51830

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What are some potential therapeutic applications of targeting Adcy9 protein? 05/04/2021

Targeting Adcy9 protein may have therapeutic applications in various diseases and conditions, including neurological disorders (such as epilepsy and Parkinson's disease), cardiovascular diseases, obesity and diabetes, and immune disorders (such as autoimmune diseases and cancer).

What are some potential biomarkers for monitoring the efficacy of Adcy9-targeted therapies? 03/04/2021

As Adcy9 is involved in various signaling pathways and physiological responses, potential biomarkers for monitoring the efficacy of Adcy9-targeted therapies may depend on the disease or condition being treated. For example, in neurological disorders, biomarkers such as seizure frequency, dopamine levels, and neuroimaging measures may be used. In cardiovascular diseases, biomarkers such as blood pressure and heart rate may be monitored. In immune disorders, biomarkers such as cytokine levels and immune cell function may be measured.

What are some of the challenges in developing Adcy9-targeted therapies? 01/30/2021

One challenge in developing Adcy9-targeted therapies is identifying drugs that specifically modulate Adcy9 activity without affecting other cAMP-producing enzymes. Another challenge is understanding the complex interactions between cAMP signaling pathways and other signaling pathways in the brain and throughout the body. These factors highlight the need for further research to develop effective and safe therapies targeting Adcy9.

What techniques are used to study Adcy9 protein? 04/02/2020

Researchers use a variety of techniques to study Adcy9 activity and regulation, including molecular cloning, protein expression and purification, enzymatic assays, microscopy, and genetic manipulation in animal models. These techniques allow for a deeper understanding of Adcy9 function and potential therapeutic applications.

Are there any drugs in clinical trials that target Adcy9? 02/19/2020

As of 2021, there are no drugs targeting Adcy9 that have reached clinical trials. However, several small molecule inhibitors of Adcy9 are being developed by pharmaceutical companies and tested in preclinical studies.

Can Adcy9 protein be used as a biomarker for neurological disorders? 01/27/2020

While Adcy9 has been implicated in various neurological disorders, it may not be specific enough as a biomarker for these disorders. Further research is needed to identify more specific biomarkers for diagnosis and monitoring of neurological disorders.

Can Adcy9 protein be a target for drug development? 12/06/2019

Yes, Adcy9 has been identified as a potential therapeutic target for various neurological disorders such as depression, anxiety, and addiction. There is ongoing research to develop drugs that modulate Adcy9 activity, either by inhibiting or enhancing its function, as a potential treatment strategy for these disorders.

Can genetic mutations in Adcy9 protein cause disease? 10/02/2018

Yes, genetic mutations in Adcy9 have been associated with various neurological disorders, such as bipolar disorder, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). These mutations can affect the function and regulation of Adcy9, leading to changes in cAMP levels and neuronal signaling that contribute to the development of these disorders.

What are some challenges in developing Adcy9-targeted therapies? 04/26/2018

One challenge in developing Adcy9-targeted therapies is that Adcy9 is not the only adenylate cyclase isoform expressed in cells and tissues, and its physiological roles and functions may overlap with those of other adenylate cyclases. This may lead to off-target effects and toxicity of Adcy9-specific drugs. Additionally, the complex regulation and interactions of Adcy9 with other signaling pathways may complicate the design and optimization of Adcy9-targeted therapeutics.

What are some other potential applications of Adcy9 protein research? 08/14/2017

In addition to its potential role in neurological disorders, Adcy9 research may have applications in other areas such as obesity and diabetes. Studies have shown that cAMP signaling can affect glucose and lipid metabolism, and Adcy9 has been linked to insulin resistance in obesity and type 2 diabetes. Therefore, targeting Adcy9 activity may have potential therapeutic benefits for these conditions.

How is Adcy9 being targeted for drug development? 06/12/2017

Various approaches are being explored for targeting Adcy9 protein in drug development, including small molecule inhibitors, RNA interference (RNAi), and gene therapy. Small molecule inhibitors that target Adcy9 activity or expression are being developed and tested in preclinical studies. RNAi technology is being used to silence Adcy9 expression in cells and animal models, and gene therapy approaches are being explored to deliver Adcy9-targeted therapeutics to specific tissues.

How is Adcy9 protein regulated in cells? 06/08/2016

Adcy9 activity is regulated by a variety of factors including G protein-coupled receptor signaling, calcium signaling, and phosphorylation by protein kinase A. These processes can affect Adcy9 localization and stability, as well as its ability to produce cAMP.

Can measuring Adcy9 protein levels be used for diagnosis of diseases? 03/18/2016

Measuring Adcy9 protein levels alone may not be sufficient for diagnosis of diseases. However, measuring Adcy9 activity or levels in conjunction with other diagnostic tests may provide additional information for disease diagnosis, prognosis, and treatment.

Is Adcy9 protein expressed in all tissues? 07/08/2015

Adcy9 is primarily expressed in the brain, but it has also been found in other tissues including the heart, lungs, and adrenal glands. The expression levels of Adcy9 in these tissues are relatively low compared to the brain, suggesting a more specific role in neuronal signaling.

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