Recombinant Mouse Akt1 Protein, MYC/DDK-tagged


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Recombinant Mouse Akt1 Protein, MYC/DDK-tagged

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Cat.No. : Akt1-566M
Product Overview : Purified recombinant protein of full-length mouse thymoma viral proto-oncogene 1 (Akt1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : HEK293T
Species : Mouse
Molecular Mass : 56.2 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Akt1 thymoma viral proto-oncogene 1 [ Mus musculus (house mouse) ]
Official Symbol : Akt1
Synonyms : Akt1; thymoma viral proto-oncogene 1; Akt; PKB; Rac; LTR-akt; PKB/Akt; PKBalpha; RAC-alpha serine/threonine-protein kinase; AKT1 kinase; Akt1m protein; PKB alpha; RAC-PK-alpha; protein kinase B-alpha; proto-oncogene c-AKT; related to A and C kinases; tumor rejection antigen peptide pRLib; EC
Gene ID : 11651
mRNA Refseq : NM_009652
Protein Refseq : NP_033782
UniProt ID : P31750
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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