Recombinant Mouse Akt2 Protein, MYC/DDK-tagged Akt2-567M

Recombinant Mouse Akt2 Protein, MYC/DDK-tagged

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Recombinant Mouse Akt2 Protein, MYC/DDK-tagged

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Cat.No. : Akt2-567M
Product Overview : Purified recombinant protein of full-length mouse thymoma viral proto-oncogene 2 (Akt2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : One of the few specific substrates of AKT2 identified so far is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Phosphorylates CLK2 on 'Thr-343'.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 56.2 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Akt2 thymoma viral proto-oncogene 2 [ Mus musculus (house mouse) ]
Official Symbol : Akt2
Synonyms : Akt2; thymoma viral proto-oncogene 2; PKB; PKBbeta; AW554154; 2410016A19Rik; RAC-beta serine/threonine-protein kinase; PKB beta; RAC-PK-beta; protein kinase Akt-2; protein kinase B, beta; EC 2.7.11.1
Gene ID : 11652
mRNA Refseq : NM_007434
Protein Refseq : NP_031460
UniProt ID : Q60823

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