Recombinant Mouse Amer2 Protein, Myc/DDK-tagged

• Cat.No.: Amer2-1610M
• Product Overview: Purified recombinant protein of mouse full-length APC membrane recruitment 2 (Amer2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Biased expression in cerebellum adult (RPKM 8.0), whole brain E14.5 (RPKM 7.7) and 6 other tissues
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 50 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Amer2 APC membrane recruitment 2 [ Mus musculus (house mouse) ]
• Official Symbol: Amer2
• Synonyms: Amer2; APC membrane recruitment 2; Ame; Fam12; Fam123a; 2600011E07Rik; APC membrane recruitment protein 2; family with sequence similarity 123, member A; protein FAM123A
• Gene ID: 72125
• mRNA Refseq: NM_001164705
• Protein Refseq: NP_001158177
• UniProt ID: Q8CCJ4

Reviews

07/27/2021

Reduced assay variability for reliable data interpretation.

03/24/2018

High specificity in target protein localization studies.

03/03/2017

Minimal assay interference from endogenous inhibitors.

Q&As

How does AMER2 contribute to specific cellular pathways, such as Wnt signaling or cell adhesion?

AMER2 contributes to specific cellular pathways, such as Wnt signaling, by modulating the activity or localization of key pathway components.

What is the impact of AMER2 mutations on protein structure and function?

Mutations in AMER2 can impact protein structure and function, potentially affecting its interaction with binding partners or disrupting cellular processes.

How does AMER2 expression change during different stages of development?

AMER2 expression levels vary during different stages of development, with higher expression in certain tissues or cell types.

What are the regulatory mechanisms controlling AMER2 expression?

The expression of AMER2 is regulated by transcription factors, epigenetic modifications, or signaling cascades involved in cell fate determination.

What are the consequences of AMER2 knockout or overexpression in cellular processes?

AMER2 knockout or overexpression leads to alterations in cellular processes, such as proliferation, differentiation, or cell migration.

Can manipulating AMER2 expression or activity be a potential therapeutic approach for certain diseases?

Manipulating AMER2 expression or activity may hold therapeutic potential for certain diseases where dysregulation of cellular processes or signaling pathways is involved.

How does AMER2 interact with other cellular proteins or signaling pathways?

AMER2 interacts with various cellular proteins or signaling pathways, modulating their activity or participating in protein complexes.

How does AMER2 influence cellular proliferation and differentiation?

AMER2 influences cellular proliferation and differentiation through its regulatory effects on specific signaling pathways or gene expression programs.

What is the cellular localization of AMER2 protein?

AMER2 protein localizes primarily to the cytoplasm or specific subcellular compartments.

What are the functional domains of the AMER2 protein and their roles?

AMER2 protein contains functional domains involved in protein-protein interactions and potential enzymatic activities.