Recombinant Mouse Amhr2 Protein, MYC/DDK-tagged
Cat.No. : | Amhr2-474M |
Product Overview : | Purified recombinant protein of full-length mouse anti-Mullerian hormone type 2 receptor (Amhr2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 61.2 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Amhr2 anti-Mullerian hormone type 2 receptor [ Mus musculus (house mouse) ] |
Official Symbol : | Amhr2 |
Synonyms : | Amhr2; anti-Mullerian hormone type 2 receptor; C14; Mrii; Misiir; Misrii; anti-Muellerian hormone type-2 receptor; AMH type II receptor; MIS type II receptor; anti-Muellerian hormone type II receptor; anti-Mullerian hormone type 2 receptor delta 2; anti-Mullerian hormone type 2 receptor delta 9/10; EC 2.7.11.30 |
Gene ID : | 110542 |
mRNA Refseq : | NM_144547 |
Protein Refseq : | NP_653130 |
UniProt ID : | Q8K592 |
Products Types
◆ Recombinant Protein | ||
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AMHR2-505M | Recombinant Mouse AMHR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMHR2-10H | Recombinant Human AMHR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMHR2-5601H | Active Recombinant Human Anti-Mullerian Hormone Receptor, Type II, Fc-tagged | +Inquiry |
◆ Lysates | ||
AMHR2-8883HCL | Recombinant Human AMHR2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMHR2 is involved in the development and maintenance of male and female reproductive organs, including the testes, ovaries, and genital ducts.
Mutations or dysregulation of AMHR2 can lead to reproductive abnormalities, such as persistent M眉llerian duct syndrome or disorders of sexual development.
AMHR2 plays a crucial role in mediating the AMH-induced regression of M眉llerian ducts in male embryos, allowing for the development of the male reproductive system.
Besides its role in the reproductive system, AMHR2 may have additional functions in non-reproductive tissues or diseases, highlighting its potential as a therapeutic target beyond reproduction.
AMHR2 signaling pathways may cross-talk with other signaling pathways, such as the Wnt/尾-catenin or Notch pathways, to fine-tune reproductive processes and organ development.
AMHR2 expression can be influenced by genetic variations and epigenetic modifications that contribute to inter-individual differences in AMHR2 levels.
AMHR2 forms a complex with AMH ligand and the co-receptor, AMH receptor type 2 (ACVR2A), to initiate signaling cascades.
AMHR2 expression is regulated by various factors during embryonic development and tissue-specific differentiation, including transcription factors and hormonal cues.
Modulating AMHR2 signaling pathways may hold therapeutic potential for managing reproductive disorders characterized by abnormal M眉llerian duct development or function.
AMHR2 activates the Smad signaling pathway, leading to downstream gene expression changes involved in reproductive organ development and maintenance.
Customer Reviews (3)
Write a reviewReliable detection of protein-protein interaction dynamics.
Accurate determination of protein complex composition.
Compatibility with challenging sample types (e.g., crude extracts).
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