Recombinant Mouse Ap1b1 Protein, MYC/DDK-tagged
Cat.No. : | Ap1b1-618M |
Product Overview : | Purified recombinant protein of full-length mouse adaptor protein complex AP-1, beta 1 subunit (Ap1b1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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- Gene Information
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Description : | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 103.9 kDa |
Purity : | >80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ap1b1 adaptor protein complex AP-1, beta 1 subunit [ Mus musculus (house mouse) ] |
Official Symbol : | Ap1b1 |
Synonyms : | Ap1b1; adaptor protein complex AP-1, beta 1 subunit; Adtb1; b2b1660Clo; AP-1 complex subunit beta-1; adaptor protein complex AP-1 subunit beta-1; adaptor-related protein complex AP-1, beta 1 subunit; beta-adaptin 1; beta-prime adaptin; clathrin assembly protein complex 1 beta large chain; golgi adaptor HA1/AP1 adaptin beta subunit |
Gene ID : | 11764 |
mRNA Refseq : | NM_007454 |
Protein Refseq : | NP_031480 |
UniProt ID : | O35643 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionAP1B1 mutations may be associated with retinal diseases, but there are relatively few studies directly related to vision problems.
Some studies have shown that the AP1B1 gene mutation may be associated with some mental diseases such as schizophrenia.
AP1B1 mutation may affect intracellular vesicle transport and membrane protein localization, thus affecting the efficacy of therapy and the action of drugs.
Some studies have shown that mutations in the AP1B1 gene may be associated with diseases related to intellectual development.
AP1B1 mutations may be associated with a variety of diseases, including congenital retinitis pigmentosa and neurodegenerative diseases.
Gene-editing techniques such as CRISPR-Cas9 could potentially be used to fix AP1B1 mutations, but they are still in the laboratory stage and require further research and trials.
AP1B1 mutation may be hereditary, and the specific inheritance pattern may be related to each specific mutation.
There is currently no specific treatment for diseases caused by AP1B1 mutations, but the quality of life of patients can be improved through symptom relief treatment and rehabilitation training.
AP1B1 plays an important role in cell regulation by participating in intracellular vesicle transport and cell membrane protein localization.
AP1B1 mutation may lead to the abnormality of intracellular signal transduction pathway and affect the normal process of various biochemical reactions in the cell.
There is currently no direct way to prevent AP1B1 mutations, but a healthy lifestyle and genetic counseling may help reduce the risk of certain genetic diseases.
Recent studies have shown that AP1B1 plays an important role in intracellular vesicle transport and neuronal development.
It is unclear whether AP1B1 mutations directly affect longevity.
AP1B1 gene mutation can be detected by molecular biological methods such as gene sequencing.
Customer Reviews (4)
Write a reviewReproducibility of the AP1B1 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.
AP1B1 labeling effect is very good, can be used for fluorescence labeling, etc., which is very suitable for our research.
It is very stable, even after multiple uses or storage, its structure and function remain stable, providing strong support for long-term experiments and applications.
Catalytic activity of this protein is very strong, which can make chemical reactions that are difficult to carry out easy to achieve, and has high application potential.
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