Recombinant Mouse Arhgap24 Protein, Myc/DDK-tagged
Cat.No. : | Arhgap24-1682M |
Product Overview : | Purified recombinant protein of mouse full-length Rho GTPase activating protein 24 (Arhgap24), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 73.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Arhgap24 Rho GTPase activating protein 24 [ Mus musculus (house mouse) ] |
Official Symbol : | Arhgap24 |
Synonyms : | ARHGAP24; Rho GTPase activating protein 24; rho GTPase-activating protein 24; rho-type GTPase-activating protein 24; 0610025G21Rik; MGC38749 |
Gene ID : | 231532 |
mRNA Refseq : | NM_146161 |
Protein Refseq : | NP_666273 |
UniProt ID : | Q8C4V1 |
Products Types
◆ Recombinant Protein | ||
ARHGAP24-2581H | Recombinant Human ARHGAP24 Protein, His-tagged | +Inquiry |
ARHGAP24-421R | Recombinant Rat ARHGAP24 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGAP24-2579H | Recombinant Human ARHGAP24 Protein, MYC/DDK-tagged | +Inquiry |
ARHGAP24-765R | Recombinant Rat ARHGAP24 Protein | +Inquiry |
ARHGAP24-765H | Recombinant Human ARHGAP24 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ARHGAP24-110HCL | Recombinant Human ARHGAP24 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (11)
Ask a questionARHGAP24 is found in various species, indicating its conservation across evolution. It has been identified in mice, rats, and other mammalian species, suggesting its significance in cellular processes across different organisms.
The known interacting partners of ARHGAP24 are currently limited. However, it has been reported to interact with components of the actin cytoskeleton and other proteins involved in Rho GTPase signaling pathways. More studies are needed to identify and characterize the interacting partners of ARHGAP24.
Currently, there is limited research on ARHGAP24, and there are no well-documented knockout or knockdown studies available. More studies are needed to understand the functional consequences of ARHGAP24 loss or reduction.
There is currently no strong evidence linking ARHGAP24 to specific neurological disorders. However, since Rho GTPases are critical for neuronal development and function, further research may reveal potential implications of ARHGAP24 in neurological disorders.
The exact involvement of ARHGAP24 in signaling pathways is still being investigated. However, based on its structural characteristics, ARHGAP24 may have a role in modulating Rho GTPase signaling pathways, which are involved in various cellular processes.
Limited information is available regarding post-translational modifications of ARHGAP24. However, it is possible that ARHGAP24 undergoes modifications such as phosphorylation or acetylation, which can impact its function and activity.
Limited studies have explored the developmental role of ARHGAP24. However, it is speculated that ARHGAP24 may be involved in various developmental processes, considering the importance of Rho GTPases in cell migration, tissue morphogenesis, and neuronal development.
The therapeutic potential of targeting ARHGAP24 is yet to be explored. However, considering the involvement of Rho GTPases in various diseases, including cancer, it is plausible that modulating ARHGAP24 activity could have therapeutic benefits. Further research is needed to investigate this possibility.
Limited information is available on the genetic variations or mutations in the ARHGAP24 gene and their association with diseases. More studies are required to determine if any mutations in ARHGAP24 contribute to the onset or development of specific diseases.
Currently, there is minimal evidence linking ARHGAP24 to cancer. However, some studies suggest that alterations in Rho GTPase signaling, which can be influenced by ARHGAP24, have implications in cancer progression and metastasis. Further research is needed to determine the specific role of ARHGAP24 in cancer biology.
As of now, there is no evidence to suggest that ARHGAP24 can be used as a biomarker for any specific diseases. Further research is needed to determine its potential as a disease biomarker or therapeutic target.
Customer Reviews (8)
Write a reviewManufacturers can support researchers in developing assays to measure ARHGAP24 protein levels or activity specific to their clinical trial settings.
They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.
I am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.
Their expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the ARHGAP24 protein in my studies.
This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.
Such manufacturer support fosters a conducive environment for successful and impactful research outcomes.
The ARHGAP24 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
the manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.
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