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Recombinant Mouse ARHGAP40 Protein

Cat.No. : ARHGAP40-1876M
Product Overview : Recombinant Mouse ARHGAP40 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Arhgap40 Rho GTPase activating protein 40 [ Mus musculus ]
Official Symbol : ARHGAP40
Gene ID : 545481
mRNA Refseq : NM_001145015.1
Protein Refseq : NP_001138487.1
MIM :
UniProt ID : E9Q6X9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Is ARHGAP40 involved in any specific signaling pathways? 02/08/2023

ARHGAP40 is mainly associated with the Rho GTPase signaling pathway. It acts as a negative regulator by inactivating Rho GTPases, which are involved in various cellular processes like cell migration, cytoskeletal dynamics, and cell adhesion.

Are there any known interacting partners of ARHGAP40? 02/03/2023

The specific interacting partners of ARHGAP40 are not well characterized. However, as a Rho GTPase-activating protein (RhoGAP), ARHGAP40 may interact with various Rho GTPases, such as RhoA, Rac1, and Cdc42, to regulate their activity. Additionally, it is possible that ARHGAP40 interacts with other proteins or signaling molecules involved in cellular processes, but further research is needed to determine its exact interacting partners.

Are there any diseases or disorders associated with ARHGAP40 mutations? 01/29/2023

Currently, there are no reported diseases or disorders directly associated with ARHGAP40 mutations. However, it is possible that mutations in ARHGAP40 or dysregulation of its expression or activity could play a role in various diseases or conditions. Further research is needed to explore any potential links between ARHGAP40 mutations and specific pathology.

Is ARHGAP40 expression regulated by any transcription factors? 12/15/2022

The transcriptional regulation of ARHGAP40 has not been extensively studied, and there are no well-established transcription factors known to directly regulate its expression. However, computational analysis of the ARHGAP40 gene promoter region suggests potential binding sites for various transcription factors, including SP1, AP1, and NF-κB. Experimental studies are needed to validate the actual transcription factors involved in regulating ARHGAP40 expression.

Are there any known functional domains or motifs in ARHGAP40? 11/13/2022

Yes, ARHGAP40 contains several functional domains. It possesses a Rho-GAP domain, which is responsible for the GTPase-activating activity towards Rho GTPases. Additionally, it contains a coiled-coil domain, which is involved in protein-protein interactions.

Is there any evidence of ARHGAP40 involvement in cell proliferation or cell cycle regulation? 10/19/2022

There is limited evidence suggesting a potential role for ARHGAP40 in cell proliferation or cell cycle regulation. In some studies, ARHGAP40 has been implicated in regulating cell division and proliferation in specific cell types. However, the exact mechanisms and extent of its involvement in these processes require further investigation.

Are there any interacting proteins or binding partners of ARHGAP40? 04/30/2022

While specific binding partners of ARHGAP40 have yet to be identified, it is likely to interact with Rho GTPases due to its role in regulating their activity. Additionally, it may interact with other proteins involved in cytoskeletal dynamics and cellular processes related to Rho GTPase signaling pathways.

Does ARHGAP40 have any known roles in neuronal development and function? 06/06/2021

Although the specific roles of ARHGAP40 in neuronal development and function are not well characterized, its involvement in the regulation of Rho GTPases suggests its potential importance in these processes. Rho GTPases play critical roles in neuronal morphology, axon guidance, and synapse formation. Further research is needed to elucidate the precise functions of ARHGAP40 in neuronal processes.

Does ARHGAP40 have any role in immune system function? 05/02/2021

The potential role of ARHGAP40 in immune system function is not well understood. However, Rho GTPases, which can be regulated by ARHGAP40, have been implicated in various immune cell functions like migration, adhesion, phagocytosis, and cytokine production. It is possible that ARHGAP40 could indirectly influence immune system function through its regulation of Rho GTPases, but further research is required to determine its specific role in immune cell biology.

Is ARHGAP40 associated with any human disorders or genetic conditions? 09/04/2020

At present, there is limited information linking ARHGAP40 to human disorders or genetic conditions. Further research is necessary to investigate its potential involvement in diseases and identify any associated mutations or variations.

Does ARHGAP40 have any known interacting proteins involved in neuronal processes? 04/08/2020

Although specific interacting proteins of ARHGAP40 in neuronal processes have not been extensively identified, it is likely to interact with other molecules involved in Rho GTPase signaling, such as Rho guanine nucleotide exchange factors (GEFs) and Rho GTPase effectors, to regulate neuronal functions such as axon outgrowth and synapse formation.

Have any studies investigated the role of ARHGAP40 in diseases like neurological disorders or cancer? 01/07/2020

As of now, there is limited research exploring the potential involvement of ARHGAP40 in neurological disorders or cancer. However, since dysregulation of Rho GTPase signaling pathways has been implicated in these diseases, it is possible that alterations in ARHGAP40 expression or activity could contribute to their development. Further studies are needed to uncover its potential roles in disease contexts.

Are there any animal models available to study ARHGAP40? 08/09/2019

As of now, there are no established animal models specifically targeting ARHGAP40. However, general knockout or knockdown studies of Rho GTPase regulators or related molecules may indirectly provide insights into the function of ARHGAP40.

Are there any animal models or knockout studies related to ARHGAP40? 07/29/2019

Currently, there are no specific animal models or knockout studies available for ARHGAP40. Creating animal models or conducting knockout studies could provide valuable insights into the physiological functions and consequences of ARHGAP40 deficiency in neuronal development and function.

Are there any known small molecules or inhibitors targeting ARHGAP40? 03/05/2019

Currently, there are no known small molecules or specific inhibitors targeting ARHGAP40. Developing specific inhibitors or modulators of ARHGAP40 activity could be a potential avenue for future therapeutic interventions or research.

Does ARHGAP40 have any known mutations associated with diseases? 09/17/2018

Currently, there is limited information available regarding mutations or genetic variations in ARHGAP40 associated with human diseases. Further studies are needed to determine the specific impact of mutations in ARHGAP40 on disease development.

Is there any evidence supporting a role for ARHGAP40 in cancer? 06/20/2018

There is limited evidence suggesting a potential role for ARHGAP40 in cancer. In some studies, alterations in ARHGAP40 expression levels have been observed in certain types of cancer, including colorectal cancer and hepatocellular carcinoma. However, more research is required to establish a definitive role for ARHGAP40 in cancer development or progression.

Are there any therapeutic implications or potential targets related to ARHGAP40? 08/28/2017

Due to its involvement in the regulation of Rho GTPases, ARHGAP40 may have therapeutic implications in conditions where Rho GTPase dysregulation is implicated, such as cancer or neurological disorders. However, more research is required to fully understand its implications and identify potential therapeutic targets.

Does ARHGAP40 play a role in cytoskeletal organization? 06/11/2017

As a RhoGAP, ARHGAP40 is expected to play a role in cytoskeletal organization. Rho GTPases, such as RhoA, Rac1, and Cdc42, are known regulators of actin cytoskeleton dynamics. By catalyzing the hydrolysis of GTP to GDP on Rho GTPases, ARHGAP40 may modulate their activity and subsequently influence cytoskeletal organization and dynamics. However, further studies are necessary to elucidate the specific role of ARHGAP40 in cytoskeletal regulation.

Can ARHGAP40 be phosphorylated or undergo other post-translational modifications? 09/25/2016

Post-translational modifications of ARHGAP40 have not been extensively studied. It is unclear if ARHGAP40 can be phosphorylated or undergo other modifications like acetylation or ubiquitination.

Customer Reviews (8)

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Reviews
11/27/2022

    This specificity enables precise quantification and characterization of ARHGAP40 and its interactions with other molecules or proteins of interest.

    11/15/2021

      Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.

      01/19/2021

        They actively engage with the scientific community, staying up-to-date with the latest advancements related to ARHGAP40 protein and sharing this valuable information.

        07/13/2019

          When used in Western blotting experiments, the ARHGAP40 protein produces distinct protein bands, allowing for easy visualization and interpretation.

          02/05/2019

            In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.

            04/06/2018

              ARHGAP40 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

              05/17/2017

                The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of ARHGAP40 protein.

                12/15/2016

                  This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.

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