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Recombinant Mouse Arhgef15 Protein, Myc/DDK-tagged

Cat.No. : Arhgef15-1692M
Product Overview : Purified recombinant protein of mouse full-length Rho guanine nucleotide exchange factor (GEF) 15 (Arhgef15), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 92.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 [ Mus musculus (house mouse) ]
Official Symbol : Arhgef15
Synonyms : ARHGEF15; Rho guanine nucleotide exchange factor (GEF) 15; rho guanine nucleotide exchange factor 15; ephexin-5; E5; D130071N09; D530030K12Rik; RP23-396M19.6; MGC102247; MGC144141; MGC144142
Gene ID : 442801
mRNA Refseq : NM_177566
Protein Refseq : NP_808234
UniProt ID : Q5FWH6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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Is there any specific drug targeting ARHGEF15? 04/15/2023

Currently, there are no specific drugs or compounds that directly target ARHGEF15. However, there are drugs that target Rho GTPases or related signaling pathways, which can indirectly affect ARHGEF15 activity. These drugs could potentially be explored for their effects on ARHGEF15-mediated signaling.

What research is currently being conducted on ARHGEF15? 01/01/2023

The current research on ARHGEF15 is relatively limited, and further investigations are needed to fully understand its function and significance. However, ongoing studies may focus on elucidating its precise role in Rho GTPase regulation, identifying its binding partners and associated signaling pathways, exploring its involvement in human diseases, and investigating potential therapeutic targets for ARHGEF15-mediated processes.

Are there any animal models of ARHGEF15 knockout or overexpression? 07/03/2022

At present, there is limited information on animal models specifically targeting ARHGEF15. However, there may be generalized knockout or overexpression models of Rho GTPases or related signaling pathway components that indirectly affect ARHGEF15. These models could provide insights into the potential role of ARHGEF15 in various physiological and pathological processes. Development of specific animal models targeting ARHGEF15 could be a valuable tool for studying its function and exploring its potential therapeutic implications.

Is ARHGEF15 ubiquitously expressed or does its expression vary among cell types? 06/12/2022

ARHGEF15 expression shows some variation among cell types. While it is expressed in multiple tissues, the level of expression can differ within different types of cells or tissues. Factors such as developmental stage, cellular environment, and specific physiological conditions may influence the expression pattern of ARHGEF15 in different cell types.

What are the interactions of ARHGEF15 with other proteins? 10/16/2021

The specific protein interactions of ARHGEF15 are not extensively characterized. However, being a guanine nucleotide exchange factor (GEF), it is expected to interact with Rho GTPases and potentially other proteins involved in the regulation of the cytoskeleton. Further research is required to identify and characterize the binding partners of ARHGEF15.

Are there any known regulatory mechanisms for ARHGEF15 expression? 08/16/2021

Although information is limited, some studies suggest that ARHGEF15 expression can be regulated by various factors. For example, it has been reported that certain microRNAs (miRNAs) can interact with the mRNA of ARHGEF15 and regulate its expression levels. Additionally, other signaling pathways or transcription factors may also play a role in regulating the expression of ARHGEF15.

Are there any genetic variations or mutations associated with ARHGEF15? 12/31/2020

There is limited information available regarding genetic variations or mutations specifically associated with ARHGEF15. However, genetic studies and sequencing projects may have identified single nucleotide polymorphisms (SNPs) or other genetic variations within the ARHGEF15 gene. Further investigation is necessary to determine if any of these variations have functional implications or are associated with specific phenotypes or diseases.

Is ARHGEF15 involved in any cellular processes other than Rho GTPase regulation? 07/07/2020

While the primary known function of ARHGEF15 is its involvement in the regulation of Rho GTPases, it is possible that it may have additional roles in other cellular processes. Since Rho GTPases are key regulators of various cellular functions, it is conceivable that ARHGEF15 might indirectly influence processes such as cell cycle progression, cytoskeletal dynamics, or intracellular signaling pathways. However, further research is required to explore these potential functions.

Are there any diseases or disorders associated with ARHGEF15? 12/09/2019

Currently, there is limited information on specific diseases or disorders directly associated with ARHGEF15. However, dysregulation of Rho GTPase signaling, which ARHGEF15 is involved in, has been implicated in various pathological conditions. For example, aberrant Rho GTPase activity has been linked to cancer, neurodegenerative disorders, cardiovascular diseases, and immune disorders. Further studies are needed to determine if ARHGEF15 dysregulation contributes to the development or progression of any specific diseases.

Has ARHGEF15 been associated with any specific cellular pathways? 06/17/2019

ARHGEF15's involvement in specific cellular pathways is not well understood. However, as a guanine nucleotide exchange factor for Rho GTPases, ARHGEF15 is likely involved in signaling pathways related to cytoskeletal dynamics, cell adhesion, and migration. Rho GTPases are known to interact with multiple signaling cascades, such as the MAPK/ERK pathway, the PI3K/Akt pathway, and the Wnt signaling pathway. Further research is needed to determine the precise cellular pathways in which ARHGEF15 participates.

Are there any known drugs or therapeutic approaches targeting ARHGEF15? 02/04/2019

Are there any known drugs or therapeutic approaches targeting ARHGEF15?

Are there any known post-translational modifications of ARHGEF15? 02/02/2018

Currently, there is limited information available about post-translational modifications (PTMs) of ARHGEF15. PTMs can include phosphorylation, acetylation, ubiquitination, or glycosylation, among others, and can regulate protein function and interactions. Further research is needed to investigate if ARHGEF15 undergoes any specific PTMs and how these modifications might influence its activity or cellular localization.

Can ARHGEF15 be associated with human diseases? 07/23/2017

There is limited information regarding the involvement of ARHGEF15 in human diseases. However, some studies have suggested possible associations between ARHGEF15 and certain conditions such as cancer. Further research is needed to fully understand the potential roles of ARHGEF15 in disease progression and its clinical significance.

Is ARHGEF15 expressed in all tissues? 03/26/2017

ARHGEF15 is expressed in a variety of tissues but its expression levels can vary depending on the tissue type and developmental stage. It has been detected in various organs including the brain, heart, liver, and skeletal muscle, among others.

Is there any evidence of ARHGEF15 playing a role in cancer? 11/20/2016

There is limited research on the specific role of ARHGEF15 in cancer. However, dysregulation of Rho GTPase signaling, in which ARHGEF15 is involved, has been implicated in cancer progression and metastasis. Rho GTPases play a vital role in regulating the cytoskeleton, cell migration, and invasion, all of which are critical processes in cancer development and metastasis. Further studies are needed to determine the extent of ARHGEF15's involvement in cancer and its potential as a therapeutic target.

Does ARHGEF15 have any known interactors or binding partners? 06/05/2016

The specific binding partners or interactors of ARHGEF15 have not been extensively characterized. However, as ARHGEF15 is involved in Rho GTPase regulation, it is likely to interact with various Rho GTPases and other proteins within the signaling pathway. Identifying the precise binding partners of ARHGEF15 and understanding their functional implications is an important area of ongoing research.

Customer Reviews (8)

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Reviews
03/27/2023

    Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.

    12/26/2020

      This reliable supply chain management assures that I have uninterrupted access to the protein, allowing me to plan and conduct my experiments without concern for availability issues.

      09/24/2019

        the ARHGEF15 protein's versatility extends beyond its proven usefulness in in vitro experiments.

        02/14/2019

          With their assistance, I am confident in overcoming challenges, producing robust results, and advancing our understanding of ARHGEF15 protein and its biological significance.

          02/05/2019

            In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.

            11/12/2018

              What sets the ARHGEF15 protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.

              10/19/2017

                Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ARHGEF15 protein is an invaluable tool for researchers.

                05/17/2017

                  The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of ARHGEF15 protein.

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