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Recombinant Mouse Arpc5 Protein, Myc/DDK-tagged

Cat.No. : Arpc5-1727M
Product Overview : Purified recombinant protein of mouse full-length actin related protein 2/3 complex, subunit 5 (Arpc5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 16.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Arpc5 actin related protein 2/3 complex, subunit 5 [ Mus musculus (house mouse) ]
Official Symbol : Arpc5
Synonyms : ARPC5; actin related protein 2/3 complex, subunit 5; actin-related protein 2/3 complex subunit 5; arp2/3 complex 16 kDa subunit; p16-Arc; 5830443F10Rik
Gene ID : 67771
mRNA Refseq : NM_026369
Protein Refseq : NP_080645
UniProt ID : Q9CPW4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (9)

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Is ARPC5 essential for embryonic development? 11/28/2022

Studies in animal models have demonstrated that ARPC5 is essential for embryonic development. Knockout or depletion of ARPC5 leads to severe developmental defects, including abnormalities in neurodevelopment, highlighting its importance during embryogenesis.

Can alterations in ARPC5 expression or function affect cell migration? 06/19/2022

Yes, alterations in ARPC5 expression or function can significantly impact cell migration. Since ARPC5 is a crucial component of the ARP2/3 complex involved in actin nucleation and branching, dysregulation of ARPC5 can lead to impaired cell migration and changes in cell morphology.

Are there any known post-translational modifications of ARPC5? 09/09/2021

Currently, there is limited information available on the post-translational modifications of ARPC5. Further research is needed to investigate if ARPC5 undergoes any modifications like phosphorylation or ubiquitination, which could potentially regulate its activity and interactions.

Are there any known diseases associated with ARPC5 mutations? 12/22/2020

To date, no specific diseases have been directly linked to ARPC5 mutations. However, given its involvement in actin dynamics and cellular processes, dysregulation of ARPC5 could potentially contribute to various diseases, including those involving developmental defects or abnormalities in cell migration.

What are some current areas of active research regarding ARPC5? 06/26/2020

Current research on ARPC5 is focused on understanding its molecular mechanisms within the ARP2/3 complex, investigating its roles in cellular processes like cell migration and adhesion, and exploring its potential implications in disease progression. Additionally, there is ongoing research to identify specific regulators or modulators of ARPC5 activity for therapeutic purposes.

How does ARPC5 interact with the ARP2/3 complex? 05/29/2020

ARPC5 interacts with other subunits of the ARP2/3 complex, including ARPC2 and ARPC4, forming a stable protein complex. This interaction is necessary for the proper functioning of the ARP2/3 complex in actin nucleation.

Can ARPC5 play a role in cellular adhesion? 06/12/2019

Yes, ARPC5 can play a role in cellular adhesion through its involvement in actin dynamics. The ARP2/3 complex, including ARPC5, contributes to the formation of structures like lamellipodia and focal adhesions, which are essential for cell adhesion to the extracellular matrix.

Are there any known binding partners of ARPC5 besides the ARP2/3 complex? 12/13/2017

Apart from its interaction with the ARP2/3 complex, ARPC5 can also interact with other actin-binding proteins, such as cortactin and N-WASP (Neuronal Wiskott-Aldrich Syndrome Protein). These interactions contribute to the regulation of actin dynamics and various cellular processes.

Does ARPC5 have any role in cancer progression or metastasis? 08/22/2016

Yes, emerging evidence suggests that ARPC5 may play a role in cancer progression and metastasis. The dysregulation of actin dynamics, in which ARPC5 is involved, can affect cellular processes such as invasion and migration, which are crucial for cancer metastasis.

Customer Reviews (3)

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Reviews
06/26/2022

    Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

    08/19/2020

      the ARPC5 protein has proven to be invaluable in protein electron microscopy structure analysis.

      03/20/2020

        The ARPC5 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

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