Recombinant Mouse Atxn1 Protein, Myc/DDK-tagged

• Cat.No.: Atxn1-1782M
• Product Overview: Purified recombinant protein of mouse full-length ataxin 1 (Atxn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 83.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Atxn1 ataxin 1 [ Mus musculus (house mouse) ]
• Official Symbol: Atxn1
• Synonyms: ATXN1; ataxin 1; ataxin-1; spinocerebellar ataxia 1 homolog; Atx1; Sca1; C85907; Gm10786; 2900016G23Rik; ENSMUSG00000074917
• Gene ID: 20238
• mRNA Refseq: NM_009124
• Protein Refseq: NP_033150
• UniProt ID: P54254

Reviews

12/10/2020

Using Atxn1 as a catalyst, the rate and yield of chemical reactions can be significantly increased, and the catalytic efficiency is very high.

10/22/2019

The stability of Atxn1 is very good, and its structure and function remain stable even after several freeze-thaw cycles, which shows its excellent quality control and production process.

06/18/2019

Atxn1 are so simple to prepare that we can easily prepare them ourselves.

Q&As

How do mutations in ATXNprotein cause SCA1?

SCA1 is caused by mutations in the ATXN1 gene. The mutation resulted in the expansion of glutamine repeats in ATXN1 protein, resulting in the formation of abnormal polyglutamic acid protein. This protein abnormality can lead to abnormal neuronal function and degenerative changes, leading to the occurrence of SCA1.

Does ATXNprotein interact with other proteins?

Yes, the ATXN1 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN1 interacts with the Capicua (CIC) protein and is involved in transcriptional regulation.

Which diseases are associated with ATXNprotein?

The protein is associated with spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative disease characterized by dysfunction of the cerebellum and spinal cord, leading to ataxia and other neurological symptoms.

In which tissues is ATXNprotein expressed?

ATXN1 protein is expressed in several tissues, but its expression is higher in the central nervous system, especially in the cerebellum and spinal cord.

What is the regulatory mechanism of ATXNprotein function?

The function of ATXN1 protein is regulated by a variety of regulatory mechanisms, including post-translational modification, assembly of protein complexes, and transcriptional regulation. These regulatory mechanisms ensure the adaptability and stability of ATXN1 protein.

What is the role of ATXNprotein in humans?

ATXN1 protein is involved in the regulation of a variety of neural cell functions, including cell cycle regulation, DNA repair, transcription regulation, etc. It plays an important role in the development and functional maintenance of the nervous system.