Recombinant Mouse Bbs4 Protein, MYC/DDK-tagged

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Recombinant Mouse Bbs4 Protein, MYC/DDK-tagged

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Cat.No. : Bbs4-220M
Product Overview : Purified recombinant protein of full-length mouse Bardet-Biedl syndrome 4 (human) (Bbs4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 58.3 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Bbs4 Bardet-Biedl syndrome 4 (human) [ Mus musculus (house mouse) ]
Official Symbol : Bbs4
Synonyms : Bbs4; Bardet-Biedl syndrome 4 (human); AW537059; AW742241; D9Ertd464e; Bardet-Biedl syndrome 4 protein homolog; Bardet-Biedl syndrome 4 homolog
Gene ID : 102774
mRNA Refseq : NM_175325
Protein Refseq : NP_780534
UniProt ID : Q8C1Z7
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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