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Recombinant Mouse Bmpr2 Protein, MYC/DDK-tagged

Cat.No. : Bmpr2-715M
Product Overview : Purified recombinant protein of full-length mouse bone morphogenetic protein receptor, type II (serine/threonine kinase) (Bmpr2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 115.5 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Bmpr2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [ Mus musculus (house mouse) ]
Official Symbol : Bmpr2
Synonyms : Bmpr2; bone morphogenetic protein receptor, type II (serine/threonine kinase); BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; AL117858; AW546137; BB189135; 2610024H22Rik; bone morphogenetic protein receptor type-2; BMP type II receptor; BMP type-2 receptor; bone morphogenic protein receptor, type II (serine/threonine kinase); EC 2.7.11.30
Gene ID : 12168
mRNA Refseq : NM_007561
Protein Refseq : NP_031587
UniProt ID : O35607

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does BMPR2 play in the development and progression of pulmonary arterial hypertension (PAH)? 02/01/2022

BMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.

What is the impact of BMPR2 mutations on hereditary hemorrhagic telangiectasia? 11/19/2020

Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.

How do alterations in BMPR2 expression or signaling affect embryonic development and congenital anomalies? 05/14/2020

Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.

What are the effects of BMPR2 dysregulation on renal function and kidney disease? 05/05/2020

Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.

How does BMPR2 mediate the signaling pathways of bone morphogenetic proteins (BMPs) in bone formation and remodeling? 06/01/2019

BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.

How does BMPR2 influence cardiovascular development and disease, particularly in heart valve formation? 01/20/2019

BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.

How does BMPR2 contribute to the regulation of cell proliferation and apoptosis in various tissues? 04/18/2018

BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.

Customer Reviews (3)

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Reviews
11/20/2022

    High-quality protein crystallography services, exceptional outcomes.

    04/28/2022

      Critical expertise in protein engineering, unmatched service quality.

      07/29/2019

        Swift and reliable protein sequencing, invaluable for our research.

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