Recombinant Mouse Brd7 Protein, Myc/DDK-tagged Brd7-1890M

Recombinant Mouse Brd7 Protein, Myc/DDK-tagged

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Cat.No. : Brd7-1890M Optional Service: Optional requirements on this protein
Product Overview : Purified recombinant protein of mouse full-length bromodomain containing 7 (Brd7), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 74.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Brd7 bromodomain containing 7 [ Mus musculus (house mouse) ]
Official Symbol : Brd7
Synonyms : BRD7; bromodomain containing 7; bromodomain-containing protein 7; bromodomain-containing 7; 75 kDa bromodomain protein; bromodomain protein 75 kDa; protein tyrosine phosphatase, non-receptor type 13 interacting protein; BP75; CELTIX1; Ptpn13ip
Gene ID : 26992
mRNA Refseq : NM_012047
Protein Refseq : NP_036177
UniProt ID : O88665
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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