Recombinant Mouse Brd7 Protein, Myc/DDK-tagged

• Cat.No.: Brd7-1890M
• Product Overview: Purified recombinant protein of mouse full-length bromodomain containing 7 (Brd7), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 74.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Brd7 bromodomain containing 7 [ Mus musculus (house mouse) ]
• Official Symbol: Brd7
• Synonyms: BRD7; bromodomain containing 7; bromodomain-containing protein 7; bromodomain-containing 7; 75 kDa bromodomain protein; bromodomain protein 75 kDa; protein tyrosine phosphatase, non-receptor type 13 interacting protein; BP75; CELTIX1; Ptpn13ip
• Gene ID: 26992
• mRNA Refseq: NM_012047
• Protein Refseq: NP_036177
• UniProt ID: O88665