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Recombinant Mouse Calcoco2 Protein, Myc/DDK-tagged

Cat.No. : Calcoco2-1936M
Product Overview : Purified recombinant protein of mouse full-length calcium binding and coiled-coil domain 2 (Calcoco2), transcript variant 1, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 57 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Calcoco2 calcium binding and coiled-coil domain 2 [ Mus musculus (house mouse) ]
Official Symbol : Calcoco2
Synonyms : CALCOCO2; calcium binding and coiled-coil domain 2; calcium-binding and coiled-coil domain-containing protein 2; nuclear domain 10 protein NDP52; nuclear domain 10 protein 52 like 1; Ndp52; C77254; Ndp52l1; 2410154J16Rik
Gene ID : 76815
mRNA Refseq : NM_029755
UniProt ID : A2A6M5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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