Recombinant Mouse Ccm2 Protein, Myc/DDK-tagged

• Cat.No.: Ccm2-2045M
• Product Overview: Purified recombinant protein of mouse full-length cerebral cavernous malformation 2 (Ccm2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
• Molecular Mass: 49.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ccm2 cerebral cavernous malformation 2 [ Mus musculus (house mouse) ]
• Official Symbol: Ccm2
• Synonyms: Ccm2; cerebral cavernous malformation 2; BC029157; cerebral cavernous malformations protein 2 homolog; cerebral cavernous malformation 2 homolog; malcavernin; osmosensing scaffold for MEKK3
• Gene ID: 216527
• mRNA Refseq: NM_146014
• Protein Refseq: NP_666126
• UniProt ID: Q8K2Y9