Recombinant Mouse Cd244a Protein, Myc/DDK-tagged
| Cat.No. : | Cd244a-2057M |
| Product Overview : | Purified recombinant protein of mouse full-length CD244 molecule A (Cd244a), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
| Description : | Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis. Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells. Regulation of NK cell activity by adapters Sh2d1b and Sh2d1b2 is reported conflictingly. Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells. Involved in the regulation of CD8+ T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells. Inhibits inflammatory responses in dendritic cells (DCs). |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | Myc/DDK |
| Molecular Mass : | 45.3 kDa |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 μg/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Cd244a CD244 molecule A [ Mus musculus (house mouse) ] |
| Official Symbol : | Cd244a |
| Synonyms : | Cd244a; CD244 molecule A; Nm; 2B4; C9.1; Ly90; NAIL; Nmrk; Cd244; NKR2B4; SLAMF4; F730046O15Rik; natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; SLAM family member 4; non-MHC restricted killing associated; signaling lymphocytic activation molecule 4 |
| Gene ID : | 18106 |
| mRNA Refseq : | NM_018729 |
| Protein Refseq : | NP_061199 |
| UniProt ID : | Q07763 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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