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Recombinant Mouse Cd276 Protein, His-tagged, FITC conjugated

Cat.No. : Cd276-479MF
Product Overview : FITC conjugated recombinant Mouse Cd276 (Val29-Phe244) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
Source : HEK293
Species : Mouse
Tag : His
Form : Lyophilized
Molecular Mass : The protein has a calculated MW of 25.4 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Val29-Phe244
N-terminal Sequence Analysis : Val 29
Endotoxin : < 1.0 EU/ μg by the LAL method.
Purity : > 95 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with FITC via amines
Excitation source: 488 nm spectral line, argon-ion laser
Excitation Wavelength: 488 nm
Emission Wavelength: 535 nm
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : Cd276
Official Symbol : Cd276
Synonyms : CD276; CD276 antigen; B7-H3; B7 homolog 3; costimulatory molecule; B7h3; B7RP-2; AU016588; 6030411F23Rik
Gene ID : 102657
mRNA Refseq : NM_133983
Protein Refseq : NP_598744
UniProt ID : Q8VE98

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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In which other diseases, besides cancer, is CD276 implicated? 11/29/2022

CD276 has been associated with autoimmune diseases and certain inflammatory conditions. Exploring its role in these diseases may open avenues for therapeutic interventions.

Are there diagnostic applications for CD276 in cancer detection? 10/15/2021

Research suggests that CD276 expression levels may serve as a diagnostic biomarker for certain cancers. Detection methods, such as immunohistochemistry, are being explored to assess CD276 levels in tumor tissues.

How does CD276 influence the tumor microenvironment? 05/07/2020

CD276 can modulate the tumor microenvironment by suppressing immune responses, promoting angiogenesis, and supporting tumor cell survival. Understanding these interactions is crucial for developing targeted therapies.

Are there any ongoing clinical trials focusing on CD276 in cancer patients? 06/20/2016

Yes, several clinical trials are underway to evaluate the safety and efficacy of CD276-targeted therapies in different cancer types. These trials aim to assess the impact on patient outcomes and potential side effects.

How does CD276-targeted therapy differ from traditional cancer treatments? 02/14/2016

CD276-targeted therapy focuses on modulating the immune response against cancer cells, whereas traditional treatments like chemotherapy and radiation target rapidly dividing cells, including both healthy and cancerous cells.

Customer Reviews (3)

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Reviews
03/15/2022

    It has consistently demonstrated high sensitivity and accuracy in detecting and quantifying target molecules, allowing for precise and reliable measurement of analytes in my experimental samples.

    08/06/2021

      Its versatility and reliability make it an excellent choice for research applications, and I highly recommend it to fellow scientists.

      06/03/2021

        The sensitivity and specificity of the CD276 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.

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