Recombinant Mouse Cd80 Protein, hFc-tagged, Alexa Fluor 647 conjugated
Cat.No. : | Cd80-6898MAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant Mouse Cd80 (Val38-Lys245) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
Availability | November 06, 2024 |
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Description : | B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
Source : | HEK293 |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized |
Molecular Mass : | The protein has a calculated MW of 50.3 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Val38-Lys245 |
N-terminal Sequence Analysis : | Val 38 |
Endotoxin : | < 1.0 EU/ μg by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | Cd80 |
Official Symbol : | Cd80 |
Synonyms : | CD80; CD80 antigen; T-lymphocyte activation antigen CD80; B7 protein; activation B7-1 antigen; B71; Ly53; TSA1; Cd28l; Ly-53; MIC17 |
Gene ID : | 12519 |
mRNA Refseq : | NM_009855 |
Protein Refseq : | NP_033985 |
UniProt ID : | Q00609 |
Products Types
◆ Recombinant Protein | ||
CD80-586C | Recombinant Cynomolgus monkey CD80 Protein | +Inquiry |
CD80-0859H | Recombinant Human CD80 Protein | +Inquiry |
CD80-38H | Recombinant Human CD80 Protein (ECD), His-tagged(C-ter) | +Inquiry |
CD80-0860H | Recombinant Human CD80 Protein, His-Flag-StrepII-Tagged | +Inquiry |
CD80-1376H | Acitve Recombinant Human CD80 protein(Met1-Asn242), His&Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CD80-1767MCL | Recombinant Mouse CD80 cell lysate | +Inquiry |
CD80-948CCL | Recombinant Cynomolgus CD80 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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