Recombinant Mouse Cgas Protein, Myc/DDK-tagged

• Cat.No.: Cgas-2132M
• Product Overview: Purified recombinant protein of mouse full-length cyclic GMP-AMP synthase (Cgas), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants.
• Molecular Mass: 58.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cgas cyclic GMP-AMP synthase [ Mus musculus (house mouse) ]
• Official Symbol: Cgas
• Synonyms: Cgas; cyclic GMP-AMP synthase; Mb21d1; E330016A19Rik; cyclic GMP-AMP synthase; 2'3'-cGAMP synthase; Mab-21 domain containing 1; cGAMP synthase; mab-21 domain-containing protein 1; EC 2.7.7.86
• Gene ID: 214763
• mRNA Refseq: NM_173386
• Protein Refseq: NP_775562
• UniProt ID: Q8C6L5