Recombinant Mouse Chmp4c Protein, Myc/DDK-tagged

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Recombinant Mouse Chmp4c Protein, Myc/DDK-tagged

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Cat.No. : Chmp4c-2150M
Product Overview : Purified recombinant protein of mouse full-length charged multivesicular body protein 4C (Chmp4c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 26.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Chmp4c charged multivesicular body protein 4C [ Mus musculus (house mouse) ]
Official Symbol : Chmp4c
Synonyms : Chmp4c; charged multivesicular body protein 4C; Snf7; Shax3; Snf7-3; 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; charged multivesicular body protein 4c; Snf7 homologue associated with Alix 3; chromatin modifying protein 4C; chromatin-modifying protein 4c
Gene ID : 66371
mRNA Refseq : NM_025519
Protein Refseq : NP_079795
UniProt ID : Q9D7F7
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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