Recombinant Mouse Cnot6l Protein, Myc/DDK-tagged

• Cat.No.: Cnot6l-2222M
• Product Overview: Purified recombinant protein of mouse full-length CCR4-NOT transcription complex, subunit 6-like (Cnot6l), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 62.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cnot6l CCR4-NOT transcription complex, subunit 6-like [ Mus musculus (house mouse) ]
• Official Symbol: Cnot6l
• Synonyms: CNOT6L; CCR4-NOT transcription complex, subunit 6-like; CCR4-NOT transcription complex subunit 6-like; 4932442K20Rik; MGC29037; DKFZp434K098
• Gene ID: 231464
• mRNA Refseq: NM_144910
• Protein Refseq: NP_659159
• UniProt ID: Q8VEG6