Recombinant Mouse Commd5 Protein, Myc/DDK-tagged

• Cat.No.: Commd5-2250M
• Product Overview: Purified recombinant protein of mouse full-length COMM domain containing 5 (Commd5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 24.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Commd5 COMM domain containing 5 [ Mus musculus (house mouse) ]
• Official Symbol: Commd5
• Synonyms: Commd5; COMM domain containing 5; Hca; Hcarg; AI854466; D15Ertd81; D15Ertd81e; 2310065H03Rik; COMM domain-containing protein 5; hypertension-related, calcium regulated
• Gene ID: 66398
• mRNA Refseq: NM_025536
• Protein Refseq: NP_079812
• UniProt ID: Q8R395