Active Recombinant Mouse Ctla4 Protein, Fc-tagged
Cat.No. : | Ctla4-038M |
Product Overview : | Purified recombinant protein of Mouse cytotoxic T-lymphocyte-associated protein 4 (Ctla4) (Ala37-Phe162) with a Fc tag was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Source : | CHO |
Species : | Mouse |
Tag : | Fc |
Bio-activity : | The ED50 is 70 - 350 ng/ml, corresponding to a specific activity of 0.28-1.4 x 104 units/mg, determined by the dose dependent inhibition of IL-2 production induced by 0.5 µg/ml of CD80 on Jurkat cells |
Molecular Mass : | 41 kDa |
Endotoxin : | Less than 0.01 ng per µg protein as determined by the LAL method |
Purity : | >95%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | Protein formulated and vialed at >50 ug/mL in specified buffer |
Storage Buffer : | 1 x PBS |
Gene Name : | Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Ctla4 |
Synonyms : | Ctla4; cytotoxic T-lymphocyte-associated protein 4; Cd152; Ly-56; Ctla-4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4 |
Gene ID : | 12477 |
mRNA Refseq : | NM_009843 |
Protein Refseq : | NP_033973 |
UniProt ID : | P09793 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
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