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Active Recombinant Mouse Ctla4 Protein, Fc-tagged

Cat.No. : Ctla4-038M
Product Overview : Purified recombinant protein of Mouse cytotoxic T-lymphocyte-associated protein 4 (Ctla4) (Ala37-Phe162) with a Fc tag was expressed in CHO cell.
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  • Gene Information
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Description : This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Source : CHO
Species : Mouse
Tag : Fc
Bio-activity : The ED50 is 70 - 350 ng/ml, corresponding to a specific activity of 0.28-1.4 x 104 units/mg, determined by the dose dependent inhibition of IL-2 production induced by 0.5 µg/ml of CD80 on Jurkat cells
Molecular Mass : 41 kDa
Endotoxin : Less than 0.01 ng per µg protein as determined by the LAL method
Purity : >95%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Storage : Store at -80 centigrade.
Concentration : Protein formulated and vialed at >50 ug/mL in specified buffer
Storage Buffer : 1 x PBS
Gene Name : Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ]
Official Symbol : Ctla4
Synonyms : Ctla4; cytotoxic T-lymphocyte-associated protein 4; Cd152; Ly-56; Ctla-4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4
Gene ID : 12477
mRNA Refseq : NM_009843
Protein Refseq : NP_033973
UniProt ID : P09793

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there ongoing clinical trials exploring CTLA-4 inhibitors in combination with other immunotherapies? 05/16/2020

Yes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.

How does the expression of CTLA-4 vary in different types of immune cells? 10/17/2019

CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.

In what ways can CTLA-4 be utilized in organ transplantation? 01/11/2017

Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.

How does CTLA-4 contribute to the maintenance of immune tolerance? 04/30/2016

CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.

How does CTLA-4 blockade differ from PD-1/PD-L1 blockade in cancer immunotherapy? 03/18/2016

While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.

Customer Reviews (3)

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Reviews
04/17/2019

    It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

    11/25/2018

      The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.

      01/28/2017

        the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.

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