Active Recombinant Mouse Cx3cl1 Protein
Cat.No. : | Cx3cl1-2385M |
Product Overview : | Purified recombinant protein of Mouse chemokine (C-X3-C motif) ligand 1 (Cx3cl1 / Fractalkine) without tag was expressed in E. coli. |
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Description : | Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. |
Source : | E. coli |
Species : | Mouse |
Bio-activity : | Bioactivity was measured by its property to chemoattract BaF3-mCX3CR1 transfectants in a dose dependent manner. |
Molecular Mass : | 9.59 kDa |
Protein length : | Leu22-Lys105 |
Endotoxin : | Less than 0.01 ng/μg protein as determined by the LAL method |
Purity : | > 98%, as determined by Coomassie stained SDS-PAGE. |
Stability : | Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | Protein formulated and vialed at >50 μg/mL in specified buffer |
Storage Buffer : | 10 mM NaH2PO4, 0.15 M NaCl, pH 7.2 |
Gene Name : | Cx3cl1 chemokine (C-X3-C motif) ligand 1 [ Mus musculus (house mouse) ] |
Official Symbol : | Cx3cl1 |
Synonyms : | CX3CL1; chemokine (C-X3-C motif) ligand 1; fractalkine; neurotactin; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D, 1; CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747; D8Bwg0439e |
Gene ID : | 20312 |
mRNA Refseq : | NM_009142 |
Protein Refseq : | NP_033168 |
UniProt ID : | O35188 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.
Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.
CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.
Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.
Customer Reviews (3)
Write a reviewthe CX3CL1 protein's compatibility with various experimental techniques further supports its usability.
One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.
Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.
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