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Recombinant Mouse CXCL10 (IP-10)

Cat.No. : CXCL10-71M
Product Overview : Mouse IP-10/CXCL10 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Description : C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is a member of the C-X-C chemokine family. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3.
Source : Yeast
Species : Mouse
Form : Lyophilized
Molecular Mass : 8.7 kDa
AA Sequence : IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP (77)
Applications : The mouse IP-10/CXCL10 protein can be used in cell culture, as an IP-10/CXCL10 ELISA Standard, and as a Western Blot Control.
Storage : -20 C
Gene Name : Cxcl10 chemokine (C-X-C motif) ligand 10 [ Mus musculus ]
Official Symbol : CXCL10
Synonyms : CXCL10; chemokine (C-X-C motif) ligand 10; C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10; C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10;
Gene ID : 15945
mRNA Refseq : NM_021274
Protein Refseq : NP_067249
Pathway : Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem;
Function : chemokine activity; cytokine activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which CXCL10 modulates the blood-brain barrier and affects neuroinflammatory diseases? 10/21/2022

CXCL10 affects the blood-brain barrier, playing a role in neuroinflammatory disorders.

What is the impact of CXCL10 on the pathogenesis of autoimmune diseases, like rheumatoid arthritis and lupus? 09/28/2021

CXCL10 plays a role in autoimmune diseases, exacerbating conditions like rheumatoid arthritis and lupus.

What role does CXCL10 play in the tumor microenvironment and cancer metastasis? 11/10/2020

In cancer, CXCL10 influences the tumor microenvironment and may contribute to tumor spread and metastasis.

How do alterations in CXCL10 expression or signaling affect the progression of chronic inflammatory conditions? 06/08/2020

Changes in CXCL10 expression influence chronic inflammatory diseases, potentially aggravating or modulating disease progression.

How does CXCL10 contribute to the antiviral immune response, particularly in viral hepatitis and HIV infections? 11/03/2019

CXCL10 is important in antiviral defense, enhancing immune responses against pathogens like hepatitis viruses and HIV.

How does CXCL10 influence angiogenesis and tissue repair processes? 09/09/2019

CXCL10 impacts angiogenesis and is involved in tissue repair and regeneration processes.

How does CXCL10 mediate immune cell recruitment and activation in inflammatory and infectious diseases? 07/30/2019

CXCL10 attracts and activates immune cells to sites of inflammation and infection, coordinating the immune response.

Customer Reviews (3)

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Reviews
07/18/2019

    Expertise in protein engineering, invaluable for our laboratory's needs.

    03/01/2019

      Swift protein characterization services, essential for our research projects.

      01/23/2018

        High-quality protein-protein interaction assays, integral to our experiments.

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