Recombinant Mouse Ddr2 Protein, Myc/DDK-tagged

• Cat.No.: Ddr2-2496M
• Product Overview: Purified recombinant protein of mouse full-length discoidin domain receptor family, member 2 (Ddr2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 96.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ddr2 discoidin domain receptor family, member 2 [ Mus musculus (house mouse) ]
• Official Symbol: Ddr2
• Synonyms: DDR2; discoidin domain receptor family, member 2; discoidin domain-containing receptor 2; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; receptor protein-tyrosine kinase TKT; neurotrophic tyrosine kinase, receptor-related 3; Ntrkr3; tyro10; AW495251
• Gene ID: 18214
• mRNA Refseq: NM_022563
• Protein Refseq: NP_072075
• UniProt ID: Q62371