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Recombinant Mouse Ddx1 Protein, MYC/DDK-tagged
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| Cat.No. : | Ddx1-266M |
| Product Overview : | Purified recombinant protein of full-length mouse DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 (Ddx1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
| Description : | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA. |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | MYC/DDK |
| Molecular Mass : | 82.5 kDa |
| Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 ug/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Ddx1 DEAD box helicase 1 [ Mus musculus (house mouse) ] |
| Official Symbol : | Ddx1 |
| Synonyms : | Ddx1; DEAD box helicase 1; DBP-RB; AA409185; ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1; EC 3.6.4.13 |
| Gene ID : | 104721 |
| mRNA Refseq : | NM_134040 |
| Protein Refseq : | NP_598801 |
| UniProt ID : | Q91VR5 |
◆ Recombinant Protein
| DDX1-2461H | Recombinant Human DDX1 Protein, GST-tagged | +Inquiry |
| DDX1-4893H | Recombinant Human DDX1 Protein, Myc/DDK-tagged | +Inquiry |
| DDX1-4397M | Recombinant Mouse DDX1 Protein | +Inquiry |
| DDX1-1816R | Recombinant Rat DDX1 Protein | +Inquiry |
| DDX1-26545TH | Recombinant Human DDX1 | +Inquiry |
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◆ Lysates
| DDX1-7021HCL | Recombinant Human DDX1 293 Cell Lysate | +Inquiry |
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DDX1DDX21DDX3YDDX4DDX41DDX43DDX54DDX56DDX6DDX11DDX20DDX17DDX3XDDX47DDX50DDX5DDX39ADDX24DDX39BDDX55DDX58DDX52DDX53DDX19BDDX25DDX26BDDX27DDX23DDX10DDX18DDX59DDX19ADDX51DDX28DDX31DDX42DDX46DDX49DDX60LDDX60
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