Recombinant Mouse Def6 Protein, Myc/DDK-tagged

• Cat.No.: Def6-2517M
• Product Overview: Purified recombinant protein of mouse full-length differentially expressed in FDCP 6 (Def6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of systemic autoimmunity.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 73.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Def6 differentially expressed in FDCP 6 [ Mus musculus (house mouse) ]
• Official Symbol: Def6
• Synonyms: DEF6; differentially expressed in FDCP 6; DEF-6; IRF4-binding protein; IRF-4-binding protein; SWAP-70-like adapter of T-cells; Ibp; Slat; Slat2; Slat6; AV094905; 2410003F05Rik; 6430538D02Rik
• Gene ID: 23853
• mRNA Refseq: NM_027185
• Protein Refseq: NP_081461
• UniProt ID: Q8C2K1