Recombinant Mouse Dis3l2 Protein, Myc/DDK-tagged

• Cat.No.: Dis3l2-2570M
• Product Overview: Purified recombinant protein of mouse full-length DIS3 like 3'-5' exoribonuclease 2 (Dis3l2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 97.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dis3l2 DIS3 like 3'-5' exoribonuclease 2 [ Mus musculus (house mouse) ]
• Official Symbol: Dis3l2
• Synonyms: DIS3L2; DIS3 mitotic control homolog (S. cerevisiae)-like 2; DIS3-like exonuclease 2; 4930429A22Rik; 8030493P09Rik; MGC37640
• Gene ID: 208718
• mRNA Refseq: NM_153530
• Protein Refseq: NP_705758
• UniProt ID: Q8CI75