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Recombinant Mouse Dnajc3 Protein, MYC/DDK-tagged
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| Cat.No. : | Dnajc3-006M |
| Product Overview : | Purified recombinant protein of full-length mouse DnaJ heat shock protein family (Hsp40) member C3 (Dnajc3), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
| Description : | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| Source : | HEK293T |
| Species : | Mouse |
| Tag : | MYC/DDK |
| Molecular Mass : | 57.5 kDa |
| Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade after receiving vials. |
| Concentration : | >50 ug/mL as determined by microplate BCA method |
| Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Gene Name : | Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ] |
| Official Symbol : | Dnajc3 |
| Synonyms : | Dnajc3; DnaJ heat shock protein family (Hsp40) member C3; p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b; AA408985; AU067833; dnaJ homolog subfamily C member 3; DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ (Hsp40) homolog, subfamily C, member 3A; DnaJ (Hsp40) homolog, subfamily C, member 3B; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein kinase, interferon inducible double stranded RNA dependent inhibitor |
| Gene ID : | 100037258 |
| mRNA Refseq : | NM_008929 |
| Protein Refseq : | NP_032955 |
| UniProt ID : | Q91YW3 |
◆ Recombinant Protein
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| DNAJC3-2760H | Recombinant Human DNAJC3 Protein, GST-tagged | +Inquiry |
| DNAJC3-1296R | Recombinant Rhesus monkey DNAJC3 Protein, His-tagged | +Inquiry |
| DNAJC3-1822C | Recombinant Chicken DNAJC3 | +Inquiry |
| DNAJC3-26638TH | Recombinant Human DNAJC3 | +Inquiry |
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