Recombinant Mouse Dnajc3 Protein, MYC/DDK-tagged


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Recombinant Mouse Dnajc3 Protein, MYC/DDK-tagged

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Cat.No. : Dnajc3-006M
Product Overview : Purified recombinant protein of full-length mouse DnaJ heat shock protein family (Hsp40) member C3 (Dnajc3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Source : HEK293T
Species : Mouse
Molecular Mass : 57.5 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ]
Official Symbol : Dnajc3
Synonyms : Dnajc3; DnaJ heat shock protein family (Hsp40) member C3; p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b; AA408985; AU067833; dnaJ homolog subfamily C member 3; DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ (Hsp40) homolog, subfamily C, member 3A; DnaJ (Hsp40) homolog, subfamily C, member 3B; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein kinase, interferon inducible double stranded RNA dependent inhibitor
Gene ID : 100037258
mRNA Refseq : NM_008929
Protein Refseq : NP_032955
UniProt ID : Q91YW3
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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