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Recombinant Mouse Dnajc3 Protein, MYC/DDK-tagged
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Cat.No. : | Dnajc3-006M |
Product Overview : | Purified recombinant protein of full-length mouse DnaJ heat shock protein family (Hsp40) member C3 (Dnajc3), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
Description : | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 57.5 kDa |
Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ] |
Official Symbol : | Dnajc3 |
Synonyms : | Dnajc3; DnaJ heat shock protein family (Hsp40) member C3; p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b; AA408985; AU067833; dnaJ homolog subfamily C member 3; DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ (Hsp40) homolog, subfamily C, member 3A; DnaJ (Hsp40) homolog, subfamily C, member 3B; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein kinase, interferon inducible double stranded RNA dependent inhibitor |
Gene ID : | 100037258 |
mRNA Refseq : | NM_008929 |
Protein Refseq : | NP_032955 |
UniProt ID : | Q91YW3 |
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