Recombinant Mouse Dpp4 Protein, Myc/DDK-tagged

• Cat.No.: Dpp4-2641M
• Product Overview: Purified recombinant protein of mouse full-length dipeptidylpeptidase 4 (Dpp4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 87.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dpp4 dipeptidylpeptidase 4 [ Mus musculus (house mouse) ]
• Official Symbol: Dpp4
• Synonyms: DPP4; dipeptidylpeptidase 4; dipeptidyl peptidase 4; DPP IV; dipeptidyl peptidase IV; thymocyte-activating molecule; T-cell activation antigen CD26; Cd26; THAM; Dpp-4
• Gene ID: 13482
• mRNA Refseq: NM_010074
• Protein Refseq: NP_034204
• UniProt ID: P28843