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Recombinant Mouse Eed Protein, Myc/DDK-tagged

Cat.No. : Eed-2732M
Product Overview : Purified recombinant protein of mouse full-length embryonic ectoderm development (Eed), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 50.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Eed embryonic ectoderm development [ Mus musculus (house mouse) ]
Official Symbol : Eed
Synonyms : EED; embryonic ectoderm development; polycomb protein EED; lethal, Chr 7, Rinchik 5; lusk; l7Rn5; l(7)5Rn; ENSMUSG00000039373
Gene ID : 13626
mRNA Refseq : NM_021876
Protein Refseq : NP_068676
UniProt ID : Q921E6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of EED dysregulation on the development of cancer, especially in terms of epigenetic alterations? 08/18/2022

Dysregulation of EED can lead to cancer, largely through epigenetic alterations and disrupted gene regulation.

How does EED contribute to the maintenance of pluripotency and self-renewal in stem cells? 04/26/2022

EED helps maintain stem cell pluripotency and self-renewal capabilities, crucial for embryonic development.

How does EED interact with the Polycomb repressive complex 2 (PRC2) in chromatin remodeling? 05/05/2021

EED works with PRC2 in chromatin remodeling, influencing gene silencing and cellular identity.

How do alterations in EED expression or function affect developmental disorders and congenital anomalies? 10/26/2020

Changes in EED function impact developmental processes, potentially leading to congenital anomalies and disorders.

How does EED regulate epigenetic modifications, particularly histone methylation, in gene expression? 10/18/2020

EED regulates gene expression by modulating histone methylation, affecting epigenetic landscapes.

What role does EED play in the development and differentiation of embryonic stem cells? 06/28/2020

EED is essential in embryonic stem cell development, guiding differentiation processes.

What are the mechanisms by which EED influences cellular aging and senescence? 01/25/2019

EED affects cellular aging and senescence, playing a role in age-related epigenetic changes.

Customer Reviews (3)

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Reviews
12/25/2021

    Precise protein quantification, ensures data accuracy in our experiments.

    07/03/2020

      Dependable peptide synthesis, accelerates our projects effectively.

      03/02/2020

        Timely antibody validation, a valuable asset for our lab.

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