Recombinant Mouse Eed Protein, Myc/DDK-tagged
Cat.No. : | Eed-2732M |
Product Overview : | Purified recombinant protein of mouse full-length embryonic ectoderm development (Eed), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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- Gene Information
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Description : | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptional activation of facultative heterochromatin during differentiation. Required for development of secondary trophoblast giant cells during placental development. May regulate hippocampal synaptic plasticity in the developing brain. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 50.2 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Eed embryonic ectoderm development [ Mus musculus (house mouse) ] |
Official Symbol : | Eed |
Synonyms : | EED; embryonic ectoderm development; polycomb protein EED; lethal, Chr 7, Rinchik 5; lusk; l7Rn5; l(7)5Rn; ENSMUSG00000039373 |
Gene ID : | 13626 |
mRNA Refseq : | NM_021876 |
Protein Refseq : | NP_068676 |
UniProt ID : | Q921E6 |
Products Types
◆ Recombinant Protein | ||
EED-2833H | Recombinant Human EED Protein, His (Fc)-Avi-tagged | +Inquiry |
EED-1206R | Recombinant Rhesus Macaque EED Protein, His (Fc)-Avi-tagged | +Inquiry |
EED-2644M | Recombinant Mouse EED Protein, His (Fc)-Avi-tagged | +Inquiry |
EED-410H | Recombinant Human EED Protein, His-tagged | +Inquiry |
EED-3063H | Recombinant Human EED Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
EED-531HCL | Recombinant Human EED cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDysregulation of EED can lead to cancer, largely through epigenetic alterations and disrupted gene regulation.
EED helps maintain stem cell pluripotency and self-renewal capabilities, crucial for embryonic development.
EED works with PRC2 in chromatin remodeling, influencing gene silencing and cellular identity.
Changes in EED function impact developmental processes, potentially leading to congenital anomalies and disorders.
EED regulates gene expression by modulating histone methylation, affecting epigenetic landscapes.
EED is essential in embryonic stem cell development, guiding differentiation processes.
EED affects cellular aging and senescence, playing a role in age-related epigenetic changes.
Customer Reviews (3)
Write a reviewPrecise protein quantification, ensures data accuracy in our experiments.
Dependable peptide synthesis, accelerates our projects effectively.
Timely antibody validation, a valuable asset for our lab.
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