Recombinant Mouse Eif3d Protein, Myc/DDK-tagged
Cat.No. : | Eif3d-2778M |
Product Overview : | Purified recombinant protein of mouse full-length eukaryotic translation initiation factor 3, subunit D (Eif3d), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 64 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Eif3d eukaryotic translation initiation factor 3, subunit D [ Mus musculus (house mouse) ] |
Official Symbol : | Eif3d |
Synonyms : | EIF3D; eukaryotic translation initiation factor 3, subunit D; eukaryotic translation initiation factor 3 subunit D; eIF3 p66; eIF-3-zeta; translation initiation factor eIF3 p66; eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3, subunit 7 (zeta); Eif3s7; eIF3p66; 66/67kDa; AA407891; MGC115774 |
Gene ID : | 55944 |
mRNA Refseq : | NM_018749 |
Protein Refseq : | NP_061219 |
UniProt ID : | O70194 |
Products Types
◆ Recombinant Protein | ||
EIF3D-3178H | Recombinant Human EIF3D Protein, GST-tagged | +Inquiry |
EIF3D-1245R | Recombinant Rhesus Macaque EIF3D Protein, His (Fc)-Avi-tagged | +Inquiry |
EIF3D-326H | Recombinant Human EIF3D Protein, MYC/DDK-tagged | +Inquiry |
EIF3D-1715R | Recombinant Rat EIF3D Protein, His (Fc)-Avi-tagged | +Inquiry |
EIF3D-2711M | Recombinant Mouse EIF3D Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
EIF3D-6663HCL | Recombinant Human EIF3D 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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