Recombinant Mouse Eif3e Protein, Myc/DDK-tagged


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Recombinant Mouse Eif3e Protein, Myc/DDK-tagged

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Cat.No. : Eif3e-2779M
Product Overview : Purified recombinant protein of mouse full-length eukaryotic translation initiation factor 3, subunit E (Eif3e), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 52.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Eif3e eukaryotic translation initiation factor 3, subunit E [ Mus musculus (house mouse) ]
Official Symbol : Eif3e
Synonyms : EIF3E; eukaryotic translation initiation factor 3, subunit E; eukaryotic translation initiation factor 3 subunit E; eIF-3 p48; MMTV integration site 6; mammary tumor integration site 6; viral integration site protein INT-6; mammary tumor-associated protein INT-6; eukaryotic translation initiation factor 3 subunit 6; eukaryotic translation initiation factor 3, subunit 6 48kDa; Int6; 48kDa; Eif3s6; eIF3-p46; eIF3-p48
Gene ID : 16341
mRNA Refseq : NM_008388
Protein Refseq : NP_032414
UniProt ID : P60229
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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